Nobiletin alleviates endometriosis via down-regulating NF-κB activity in endometriosis mouse model

Xin Wei, Xu Shao
Bioscience reports · 2018 · vol. 38(3) · doi:10.1042/bsr20180470 · PMID:29871974 · W2805153789
article OA: gold CC0 ⤵ 27 in-corpus citations
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Nobiletin administration reduced endometriosis lesion size and pain in mice by down-regulating NF-κB activity, specifically inhibiting IκB kinase activation.

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Abstract

alleviation of nobiletin on endometriosis and its mechanism of action. The mouse model of endometriosis was established and administered with nobiletin. The ectopic lesion size was measured and the hotplate test was performed to assess the amelioration of nobiletin on endometriosis. The expression of proliferation and angiogenesis relevant genes including proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF), and E-cadherin was measured by immunostaining and the mRNA expression of proinflammatory mediators including interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, matrix metalloproteinases (MMP)-1, and MMP-3 was measured by RT-PCR. The change of NF-κB activity in endometriotic cells was evaluated by Western blotting and confirmed by luciferase assay. Administration of nobiletin significantly reduced lesions size and pain in endometriosis mice. Nobiletin significantly altered the expression of PCNA, VEGF, and E-cadherin in ectopic endometrium, as well as the levels of IL-6, IL-1β, TNF-α, MMP-1, and MMP-3. Nobiletin also showed remarkably impairment on the activation of NF-κB in promoting endometriotic cells, likely targeting on the activity of IκB kinases (IKKs). The present study provides the first evidence that nobiletin exerts protection on endometriosis via inhibition the activation of NF-κB, specifically on the activity of IκB kinases.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Anti-Inflammatory Agents Choristoma Endometriosis Flavones NF-kappa B Nociception Animals Anti-Inflammatory Agents Cadherins Cadherins Cadherins Choristoma Choristoma Choristoma Choristoma Disease Models, Animal Ectopic Gene Expression Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (39)

Cited by (27)

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