Does hysterectomy with ovarian conservation affect bone metabolism and density?

Sulin Cheng, Harri Sievänen, Ari Heinonen, Kristi Uusi-Rasi, K. Uusi-Rasi, Laura Carbone, Frances A. Tylavsky, Frances Tylavsky, Jussi Halleen, Jussi M. Halleen, Pekka Kannus
Journal of bone and mineral metabolism · 2003 · vol. 21(1) , pp. 12–16 · doi:10.1007/s007740300002 · PMID:12491088 · W2059763873
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Among postmenopausal women, hysterectomy with ovarian conservation was associated with higher bone mineral density at the femoral neck and lumbar spine alongside altered bone turnover markers compared to those without such history.

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Abstract

We evaluated whether hysterectomy with ovarian conservation (HYX) has an effect on bone metabolism and density in 176 healthy Caucasian postmenopausal women aged 48-59 years. Bone properties of the hip, spine, radius, tibia, and calcaneus were measured using different bone assessment modalities. In addition, bone turnover was assessed using serum bone-specific alkaline phosphatase (BAP), osteocalcin (OC), and tartrate-resistant acid phosphatase (TRAP) 5b as biomarkers. Our results showed that women having HYX had a significantly lower level of OC ( P = 0.017) and a marginally lower level of TRAP 5b ( P = 0.051) and higher bone mineral density (BMD) of the femoral neck ( P = 0.037) and lumbar spine ( P= 0.001) than women with no history of HYX. In addition, the cortical BMD and bone strength index (I(polar)) of the tibia also showed higher values at different sections in women having HYX than women with no history of HYX ( P = 0.055 to P< 0.005). These results suggest that the uterus may have a role in regulating bone metabolism that has not been detected previously.

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MeSH descriptors

Bone and Bones Bone Density Hysterectomy Ovary Bone and Bones Female Follicle Stimulating Hormone Follicle Stimulating Hormone Humans Middle Aged Ovary Postmenopause

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