[Hormonal premedication in endometrium ablation--results of a prospective comparative study]
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⤵ 4 in-corpus citations
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Danazol and GnRH-analogon premedication improved endometrial ablation outcomes, resulting in thinner endometria, better coagulation, and higher amenorrhea rates compared to no pretreatment.
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Abstract
In a prospective study in 40 patients the pretreatment for endometrial ablation with a gestagen (Orgametril 10 mg/die), danazol (600 mg/die) and an injection of a GnRH-analogon (Decapeptyl-Depot) was compared with a control group without pretreatment. The subjective estimation of the surgeon (endometrial thickness and depth of coagulation) showed a sufficient pretreatment in 90 % of all cases following danazol- and GnRH-analogon-pretreatment. In 90 % of the danazol- and GnRH-analogon pretreated group the histological findings showed also an atrophic or little proliferative endometrium. In a follow up of 6 months after endometrial ablation the highest amenorrhoea-rates were reached following danazol- and GnRH-analogon pretreatment. These two regimes should be used for the pretreatment for endometrial ablation.
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Cited by (4)
- Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding 2013
- Medical preparation of the endometrium prior to resection: Decapeptyl SR (triptorelin) versus danazol versus placebo 1998
- Variation of outcome reporting in studies of interventions for heavy menstrual bleeding: a systematic review 2022
- Response of the Uterus to Medication: Hysteroscopic Implications 2009
Cited by (4)
- Variation of outcome reporting in studies of interventions for heavy menstrual bleeding: a systematic review 2022
- Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding 2013
- Response of the Uterus to Medication: Hysteroscopic Implications 2009
- Medical preparation of the endometrium prior to resection: Decapeptyl SR (triptorelin) versus danazol versus placebo 1998
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- openalex
- last seen: 2026-05-10T11:05:14.263564+00:00
- pubmed
- last seen: 2026-10-08T21:59:49.088203+00:00
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