The endometria of patients with endometriosis show higher expression of class I human leukocyte antigen than the endometria of healthy women

M. Vernet-Tomás, María del Mar Vernet-Tomás, Vernet-Tomás Mdel M, Carlos Tomás Pérez-Ares, Carlos T Pérez-Ares, Pérez-Ares CT, Verdú N, Núria Verdú, José Luis Rodríguez Molinero, Molinero JL, José Luis Molinero, María Teresa Fernández-Figueras, María Teresa Fernández‐Figueras, Ramón Carreras, Ramon Carreras, Carreras R
Fertility and sterility · 2006 · vol. 85(1) , pp. 78–83 · doi:10.1016/j.fertnstert.2005.06.057 · PMID:16412734 · W2144130858
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Endometriosis patient endometria exhibit significantly increased expression of class I human leukocyte antigen compared to healthy control endometria.

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Abstract

OBJECTIVE: To compare the expression of class I human leukocyte antigen (HLA I) in endometrial samples from patients with and without endometriosis. DESIGN: Cross-sectional study. SETTING: Acute-care teaching hospital in Barcelona, Spain. PATIENT(S): The endometriosis group included 32 patients for whom the only diagnosis during an operation was endometriosis. The control group included 20 women who underwent a laparoscopy and in whom no evidence of endometriosis or any other genital disease was seen. INTERVENTION(S): Samples of endometrium were obtained by curettage and immediately frozen. A pan-HLA I mouse antihuman IgG2a monoclonal antibody was used for immunohistochemical study. MAIN OUTCOME MEASURE(S): Frequency of positive glandular and stromal cells was evaluated in each section. RESULT(S): A significantly higher expression of HLA I in the endometriosis group than in controls, both in the glandular cells (median 100% vs. 80%) and in the stromal cells (median 60% vs. 20%), was observed. CONCLUSION(S): Patients with endometriosis had a significantly higher expression of HLA I molecules in endometrial cells than did the controls. This could be a possible explanation for their higher resistance to natural killer cytolysis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Histocompatibility Antigens Class I Adult Adult Cross-Sectional Studies Cross-Sectional Studies Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Histocompatibility Antigens Class I Histocompatibility Antigens Class I Histocompatibility Antigens Class I Humans Humans

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