Xanthogranulomatous cholangitis causing obstructive jaundice: a case report

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A 34-year-old woman with xanthogranulomatous cholangitis causing obstructive jaundice was initially misdiagnosed with adenocarcinoma, highlighting the diagnostic challenge of distinguishing benign from malignant hepatic hilar strictures.

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Abstract

This article reports the case of a 34-year-old woman with xanthogranulomatous cholangitis who developed obstructive jaundice. Microscopically, the bile duct was surrounded and narrowed by a xanthogranulomatous lesion, but no xanthogranulomatous cholecystitis was seen. Although percutaneous cholangiograms done via the transhepatic biliary drainage showed smooth narrowing of the upper to middle bile duct, the cytology of bile was diagnosed as class V adenocarcinoma. Therefore, right extended hepatectomy and extrahepatic bile duct resection were performed. The differentiation of benign and malignant strictures at the hepatic hilum is often difficult. Xanthogranulomatous cholangitis is one possible diagnosis of a bile duct stricture. Precise review of all the preoperative information is required to make a correct diagnosis.

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MeSH descriptors

Cholangitis Histiocytosis, Non-Langerhans-Cell Jaundice, Obstructive Adenocarcinoma Adenocarcinoma Adenocarcinoma Adult Bile Duct Neoplasms Bile Duct Neoplasms Bile Duct Neoplasms Bile Ducts, Intrahepatic Bile Ducts, Intrahepatic Cholangitis Cholangitis Cholangitis Cholangitis Diagnosis, Differential Female Histiocytosis, Non-Langerhans-Cell Histiocytosis, Non-Langerhans-Cell

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europepmc
last seen: 2026-10-11T09:27:45.537177+00:00
pubmed
last seen: 2026-10-08T21:03:58.311020+00:00