Endometrioid adenocarcinoma presenting in a patient 18 years after hysterectomy: a potential hazard of unopposed oestrogen therapy

Alvaro Bedoya Ronga, Antonietta Ronga, Salim K Najia, S. K. Najia, Neil Sahasrabudhe, Richard Prescott, Robin Prescott, Felicia Elena Buruiana, F Buruiana, Alexander Heazell
BMJ case reports · 2009 · vol. 2009 , pp. bcr0520091829 · doi:10.1136/bcr.05.2009.1829 · PMID:21841948 · W2084646020
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This paper reports a case of endometrioid adenocarcinoma arising from extragonadal endometriosis 18 years post-hysterectomy, potentially linked to prolonged unopposed estrogen therapy.

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Abstract

We present a case of endometrioid adenocarcinoma arising from extragonadal endometriosis 18 years after total abdominal hysterectomy with bilateral salpingo-oophorectomy. After the primary surgery the patient received 11 years of unopposed oestrogen hormone replacement therapy. She presented with symptoms of urinary retention and pelvic mass. Following resection, histopathology identified the mass as an endometrioid adenocarcinoma. The association between persistent endometriosis and the development of endometrial cancer are discussed here together with the risks of unopposed oestrogen in the development of such lesions.

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endometriosis

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