Apoptosis through regulation of Bcl-2, Bax and Mcl-1 expressions in endometriotic cyst lesions and the endometrium of women with moderate to severe endometriosis

Deniz Korkmaz, D Korkmaz, Ercan Baştu, E Bastu, O Dural, Özlem Dural, Cenk Yaşa, C Yasa, E Yavuz, Ekrem Yavuz, F Buyru
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2013 · vol. 33(7) , pp. 725–728 · doi:10.3109/01443615.2013.824416 · PMID:24127964 · W2088967018
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This study found reduced Bcl-2 and Mcl-1 expression in endometriotic cyst lesions compared to the endometrium, suggesting apoptosis may contribute to endometriosis pathophysiology.

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Abstract

The aim of the study was to evaluate apoptosis through regulation of Bcl-2, Bax and Mcl-1 proteins by comparing their expressions in endometriotic cyst lesions and the endometrium of the patients with moderate to severe endometriosis. This is a cross-sectional study of 30 women in reproductive age with a clinical or sonographic suspicion of endometrioma, who underwent laparoscopy. Bcl-2 expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly reduced in the cystic endometriotic lesions (p < 0.0001). There was a significant difference in Bcl-2 expression between cystic endometriotic stromal cells and endometrial stromal cells (p < 0.0001). Bax expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly lower in the endometrium (p < 0.0001). There was a significant difference in Bax expression between cystic endometriotic stromal cells and endometrial stromal cells (p = 0.03). Mcl-1 expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly lower in the cystic endometriotic lesions (p = 0.003). Apoptosis may play a role in the pathophysiology of endometriosis by potentially contributing to the survival of regurgitating endometrial cells in the peritoneal cavity.

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Condition tags

mesh:D004715endometriosisendometrioma

MeSH descriptors

Apoptosis bcl-2-Associated X Protein Endometriosis Myeloid Cell Leukemia Sequence 1 Protein Adult bcl-2-Associated X Protein Cross-Sectional Studies Cysts Cysts Endometriosis Female Humans Myeloid Cell Leukemia Sequence 1 Protein

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