Serotonin type 2 antagonists inhibit lordosis behavior in the female rat: reversal with quipazine

Scott D. Mendelson, S D Mendelson, B B Gorzalka, Boris B. Gorzalka
Life sciences · 1986 · vol. 38(1) , pp. 33–39 · doi:10.1016/0024-3205(86)90272-9 · PMID:2934598 · W2071700753
Lab / animal OA: closed CC0 ⤵ 2 in-corpus citations
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The study investigated serotonin type 2 receptor roles in female rat lordosis behavior, finding that antagonists inhibit this behavior while the agonist quipazine reverses those effects.

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Abstract

The theory that activation of serotonin type 2 (5-HT2) receptors facilitates lordosis behavior in the female rat was tested. The 5-HT2 antagonists pizotefin, cyproheptadine, metitepine, and ketanserin were found to inhibit lordosis behavior in ovariectomized rats that had been primed with estradiol benzoate and progesterone. Pipamperone was ineffective. The 5-HT2 agonist quipazine was ineffective alone, but it reversed the inhibitory effects of pizotefin, cyproheptadine, and ketanserin. It did not reverse the effects of metitepine. The results support the theory of a facilitatory role for 5-HT2 receptors in lordosis behavior.

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MeSH descriptors

Quinolines Quipazine Serotonin Antagonists Sexual Behavior, Animal Analysis of Variance Animals Butyrophenones Butyrophenones Cyproheptadine Cyproheptadine Estradiol Estradiol Female Ketanserin Methiothepin Methiothepin Piperidines Piperidines Pizotyline Pizotyline

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Cited by (2)

References (17)

Cited by (2)

SciLite annotations

chemicals 9
serotonin ipazine cyproheptadine ketanserin estriol acetate benzoate progesterone pipamperone ipazine cyproheptadine
organisms 3
zitter rats zitter rats rattus sp.

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