Integrative whole-exome and transcriptome analyses reveal an invasion-like “motility–adhesion–cytoskeleton” program in endometriosis and validate its PI3K/AKT dependency in vitro
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Integrative whole-exome and transcriptome analyses identified an invasion-like program in endometriosis dependent on PI3K/AKT signaling, supporting it as a target for anti-invasive therapies.
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Abstract
Integrative WES–RNA‑seq profiling highlights a coordinated invasion‑like program in endometriosis with functional dependence on PI3K/AKT signaling, supporting PI3K/AKT as a mechanistically grounded target for anti‑invasive strategies in endometriosis.
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- last seen: 2026-06-06T00:00:02.894732+00:00
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