Local luteolytic effect of prostaglandin F2 alpha in the human corpus luteum

Barbro Bennegård; B Bennegård; M Hahlin; Mats Hahlin; Elisabeth Wennberg; E Wennberg; Håkan Norém; H Norén

doi:10.1016/s0015-0282(16)54719-0

Local luteolytic effect of prostaglandin F2 alpha in the human corpus luteum

Barbro Bennegård, B Bennegård, M Hahlin, Mats Hahlin, Elisabeth Wennberg, E Wennberg, Håkan Norém, H Norén

Fertility and sterility · 1991 · vol. 56(6) , pp. 1070–1076 · doi:10.1016/s0015-0282(16)54719-0 · PMID:1743324 · W2414668276

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This paper investigated the local luteolytic effect of prostaglandin F2 on the human corpus luteum, detailing its impact on luteal function.

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Abstract

OBJECTIVE: To evaluate the effects of prostaglandin (PG)F2 alpha on human corpus luteum (CL) function in vivo. DESIGN: The effects of a single injection of PGF2 alpha into the CL was studied. SETTING: The patients underwent elective surgery at the Department of Obstetrics and Gynecology, Sahlgrenska Hospital, University of Göteborg, Sweden. PARTICIPANTS: Twenty women with regular menstrual cycles undergoing laparoscopy for legal sterilization with tubal clips volunteered for the study. INTERVENTIONS: Prostaglandin F2 alpha (3 mg) was injected through the abdominal wall into the CL. In control cases, vehicle was injected into the CL or PGF2 alpha into the contralateral ovary. MAIN OUTCOME MEASURE: After the injections, serum was analyzed for progesterone (P) and luteinizing hormone using fluoroimmunoassay and enzyme-immunoassay, respectively. Menstrual data were recorded. RESULTS: In contrast to control cases, intraluteal injection of PGF2 alpha caused both an immediate fall of greater than 30% in serum P and a shortening of the luteal phase by 2 to 5 days. Luteinizing hormone varied independently of the changes in serum P levels. CONCLUSION: The results suggest a local role for PGF2 alpha in human luteolysis.

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MeSH descriptors

Corpus Luteum Dinoprost Luteolytic Agents Adult Corpus Luteum Corpus Luteum Dinoprost Female Humans Luteinizing Hormone Luteinizing Hormone Luteolysis Luteolytic Agents Progesterone Progesterone Reference Values Regional Blood Flow Regional Blood Flow

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Cites (3)

References (27)

Assessment of possible luteolytic effect on intra-ovarian injection of prostaglandin F-2ALPHA in the human via openalex
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[1] Functional activity of the corpus luteum following hysterectomy 1970

[2] Assessment of possible luteolytic effect on intra-ovarian injection of prostaglandin F-2ALPHA in the human 1975

[3] Ovarian stromal and luteal tissue prostaglandins, 17 beta-estradiol, and progesterone in relation to the phases of the menstrual cycle in women 1987