Triplet heterotopic pregnancy after gonadotropin stimulation and intrauterine insemination diagnosed at laparoscopy: a case report

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This case report describes a triplet heterotopic pregnancy diagnosed via laparoscopy in an endometriosis patient undergoing gonadotropin stimulation and intrauterine insemination for infertility.

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This case report describes a 30-year-old woman at 11 weeks gestation who presented with left lower quadrant abdominal pain, constipation, and cramps following gonadotropin stimulation and intrauterine insemination. Although initially treated empirically for diverticulitis without improvement, laparoscopic surgery revealed a heterotopic triplet pregnancy consisting of an intrauterine twin gestation and an extrauterine ectopic component. The authors emphasize that heterotopic pregnancy should remain in the differential diagnosis for first-trimester patients conceiving via assisted reproductive technology who exhibit acute abdominal symptoms. This paper is not centrally about endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Heterotopic pregnancy has been traditionally considered a rare event; however, with the use of assisted reproductive technology, the incidence of heterotopic pregnancies is increasing. Diagnosing a heterotopic pregnancy can be challenging. This report describes a 30-year-old female at 11 weeks' gestation with an intrauterine twin pregnancy after gonadotropin stimulation and intrauterine insemination who presented complaining of left lower quadrant abdominal pain with constipation and cramps. The patient was empirically treated for diverticulitis but failed to respond to therapy. A heterotopic triplet pregnancy was ultimately diagnosed at laparoscopy. Heterotopic pregnancy must be considered in the differential diagnosis of abdominal pain in the first trimester, especially in patients who conceived by means of assisted reproductive technology. Surgical treatment is the most frequently used method of treatment.
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The Southern Medical Journal (SMJ) is the official, peer-reviewed journal of the Southern Medical Association. It has a multidisciplinary and inter-professional focus that covers a broad range of topics relevant to physicians and other healthcare specialists. SMJ // Article Case Report Triplet Heterotopic Pregnancy After Gonadotropin Stimulation and Intrauterine Insemination Diagnosed at Laparoscopy: A Case Report Abstract Heterotopic pregnancy has been traditionally considered a rare event; however, with the use of assisted reproductive technology, the incidence of heterotopic pregnancies is increasing. Diagnosing a heterotopic pregnancy can be challenging. This report describes a 30-year-old female at 11 weeks' gestation with an intrauterine twin pregnancy after gonadotropin stimulation and intrauterine insemination who presented complaining of left lower quadrant abdominal pain with constipation and cramps. The patient was empirically treated for diverticulitis but failed to respond to therapy. A heterotopic triplet pregnancy was ultimately diagnosed at laparoscopy. Heterotopic pregnancy must be considered in the differential diagnosis of abdominal pain in the first trimester, especially in patients who conceived by means of assisted reproductive technology. Surgical treatment is the most frequently used method of treatment. Key Points * Heterotopic pregnancy is a rare occurrence; however, with the use of assisted reproductive technology, the incidence is increasing. * The diagnosis of heterotopic pregnancy must be considered in first-trimester pregnant patients who conceived with assisted reproductive technology and present with abdominal pain. * Several treatment modalities have been described for heterotopic pregnancies, but surgical treatment remains the most common. This content is limited to qualifying members. Existing members, please login first If you have an existing account please login now to access this article or view purchase options. Purchase only this article ($25) Create a free account, then purchase this article to download or access it online for 24 hours. Purchase an SMJ online subscription ($75) Create a free account, then purchase a subscription to get complete access to all articles for a full year. Purchase a membership plan (fees vary) Premium members can access all articles plus recieve many more benefits. View all membership plans and benefit packages.

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MeSH descriptors

Ovulation Induction Pregnancy, Ectopic Pregnancy, Ectopic Pregnancy, Multiple Abdominal Pain Abdominal Pain Adult Diagnostic Errors Diverticulitis Diverticulitis Female Humans Laparoscopy Ovulation Induction Pregnancy Pregnancy, Ectopic Pregnancy, Ectopic Triplets

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