Serological testing for celiac disease in women with endometriosis. A pilot study.

F M Aguiar, S B Castanheira Melo, L Carvalho Galvão, Lívia Carvalho Galväo, J C Rosa-e-Silva, R M dos Reis, Rosana Maria dos Reis, Rui Alberto Ferriani, R A Ferriani
Clinical and experimental obstetrics & gynecology · 2009 · vol. 36(1) , pp. 23–5 · PMID:19400413 · W49091979
article OA: closed CC0 ⤵ 15 in-corpus citations
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This pilot study found a 2.5% prevalence of celiac disease in women with endometriosis, which is higher than the 0.66% prevalence found in the control group.

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Abstract

PURPOSE OF INVESTIGATION: Celiac disease (CD) involves immunologically mediated intestinal damage with consequent micronutrient malabsorption and varied clinical manifestations, and there is a controversial association with infertility. The objective of the present study was to determine the presence of CD in a population of infertile women with endometriosis. METHODS: A total of 120 women with a diagnosis of endometriosis confirmed by laparoscopy (study group) and 1,500 healthy female donors aged 18 to 45 years were tested for CD by the determination of IgA-transglutaminase antibody against human tissue transglutaminase (t-TGA) and anti-endomysium (anti-EMA) antibodies. RESULTS: Nine of the 120 women in the study group were anti-tTGA positive and five of them were also anti-EMA positive. Four of these five patients were submitted to intestinal biopsy which revealed CD in three cases (2.5% prevalence). The overall CD prevalence among the population control group was 1:136 women (0.66%). CONCLUSION: This is the first study reporting the prevalence of CD among women with endometriosis, showing that CD is common in this population group (2.5%) and may be clinically relevant.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Celiac Disease Endometriosis Infertility, Female Adolescent Adult Autoantibodies Autoantibodies Brazil Brazil Case-Control Studies Celiac Disease Celiac Disease Celiac Disease Endometriosis Female Humans Immunoglobulin A Immunoglobulin A Infertility, Female Middle Aged

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