How does adenomyosis impact endometrial receptivity? An updated systematic review of clinical and molecular insights

Takehiro Hiraoka; Yasushi Hirota; Yutaka Osuga

doi:10.1016/j.xfnr.2022.11.004

How does adenomyosis impact endometrial receptivity? An updated systematic review of clinical and molecular insights

Takehiro Hiraoka, Yasushi Hirota, Yutaka Osuga

In: F&S Reviews · 2022 · vol. 4(1) , pp. 15–25 · doi:10.1016/j.xfnr.2022.11.004 · W4311073265

OA: closed CC0 ⤵ 5 in-corpus citations

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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This systematic review analyzes clinical and molecular data to explore how adenomyosis affects the uterus's ability to accept an embryo.

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adenomyosis

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References (100)

Adenomyosis and infertility via openalex
Adenomyosis and infertility: is there a causal link? via openalex
Adenomyosis and infertility: the role of the junctional zone via openalex
Adenomyosis: Impact on Fertility and Obstetric Outcomes via openalex
Adenomyosis in infertile women: prevalence and the role of 3D ultrasound as a marker of severity of the disease via openalex
An axonemal alteration in apical endometria of human adenomyosis via openalex
Asymptomatic adenomyosis and embryo implantation in IVF cycles via openalex
Attenuated monoamine oxidase a impairs endometrial receptivity in women with adenomyosis via downregulation of FOXO1† via openalex
Cancer-Associated Mutations in Endometriosis without Cancer via openalex
Clinical outcomes of infertility treatment for women with adenomyosis in Japan via openalex
Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium via openalex
Conservative surgical management for diffuse uterine adenomyosis via openalex
Conservative surgical treatment of adenomyosis to improve fertility: Controversial values, indications, complications, and pregnancy outcomes via openalex
Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females via openalex
Cytokine Profiling in the Eutopic Endometrium of Adenomyosis During the Implantation Window After Ovarian Stimulation via openalex
Decreased Endometrial Expression of Leukemia Inhibitory Factor Receptor Disrupts the STAT3 Signaling in Adenomyosis During the Implantation Window via openalex
Decreased Endometrial IL-10 Impairs Endometrial Receptivity by Downregulating HOXA10 Expression in Women with Adenomyosis via openalex
Decreased Indian hedgehog signaling activates autophagy in endometriosis and adenomyosis via openalex
Determining the Molecular Background of Endometrial Receptivity in Adenomyosis via openalex
Diagnosing adenomyosis: an integrated clinical and imaging approach via openalex
Diagnostic Accuracy of Transvaginal Ultrasound and Magnetic Resonance Imaging for Adenomyosis: Systematic Review and Meta-Analysis and Review of Sonographic Diagnostic Criteria via openalex
Effect of pretreatment with a levonorgestrel-releasing intrauterine system on IVF and vitrified-warmed embryo transfer outcomes in women with adenomyosis via openalex
Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis via openalex
Endometrial L-selectin ligand is downregulated in the mid-secretory phase during the menstrual cycle in women with adenomyosis via openalex
Expression of Inflammatory and Neurogenic Mediators in Adenomyosis via openalex
Expression of integrin β3 and osteopontin in the eutopic endometrium of adenomyosis during the implantation window via openalex
Expression of interleukin-8 and monocyte chemotactic protein-1 in adenomyosis via openalex
Fertility outcome of infertile women with adenomyosis treated with the combination of a conservative microsurgical technique and GnRH agonist: long-term follow-up in a series of nine patients via openalex
Fertility-Sparing Treatment of Adenomyosis in Patients With Infertility: A Systematic Review of Current Options via openalex
Four subtypes of adenomyosis assessed by magnetic resonance imaging and their specification via openalex
GnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity via openalex
How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic via openalex
HOXA10 expression is decreased in endometrium of women with adenomyosis via openalex
Impaired decidualization of human endometrial stromal cells from women with adenomyosis† via openalex
Infertility and adenomyosis via openalex
Influence of controlled ovarian hyperstimulation on uterine peristalsis in infertile women via openalex
Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of patients with adenomyosis during implantation window via openalex
Long-term pituitary downregulation before frozen embryo transfer could improve pregnancy outcomes in women with adenomyosis via openalex
Management of adenomyosis in subfertile women and pregnancy outcome via openalex
Occurrence of chronic endometritis in different types of human adenomyosis via openalex
Pituitary suppression before frozen embryo transfer is beneficial for patients suffering from idiopathic repeated implantation failure via openalex
Pregnancy rate in women with adenomyosis undergoing fresh or frozen embryo transfer cycles following gonadotropin-releasing hormone agonist treatment via openalex
Presence of adenomyosis at MRI reduces live birth rates in ART cycles for endometriosis via openalex
Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent via openalex
Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes via openalex
Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis via openalex
Reproductive Outcomes after Fertility-Sparing Surgery for Focal and Diffuse Adenomyosis: A Systematic Review via openalex
Role of transvaginal sonography and magnetic resonance imaging in the diagnosis of uterine adenomyosis via openalex
Scribble downregulation in adenomyosis compromises endometrial stromal decidualization by decreasing FOXO1 expression via openalex
Serum Osteopontin Levels Are Decreased in Focal Adenomyosis via openalex
Structural and molecular features of the endomyometrium in endometriosis and adenomyosis via openalex
Surgery for Benign Gynecological Disorders Improve Endometrium Receptivity via openalex
Surgical procedure to conserve the uterus for future pregnancy in patients suffering from massive adenomyosis via openalex
Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group via openalex
TGF-β1 Neutralization Improves Pregnancy Outcomes by Restoring Endometrial Receptivity in Mice with Adenomyosis via openalex
The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure. II: adenomyosis and macrophages via openalex
The Effect of Uterine Adenomyosis on IVF Outcomes: a Systematic Review and Meta-analysis via openalex
The impact of adenomyosis on the outcome of IVF-embryo transfer via openalex
Transcriptome analysis of eutopic endometrium in adenomyosis after GnRH agonist treatment via openalex
Transcriptomics of receptive endometrium in women with sonographic features of adenomyosis via openalex
Treatment of adenomyomectomy in women with severe uterine adenomyosis using a novel technique via openalex
Uterine adenomyosis and in vitro fertilization outcome: a systematic review and meta-analysis via openalex
Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations via openalex
Uterine innervation in adenomyosis via openalex
Uterine junctional zone at magnetic resonance imaging: a predictor of in vitro fertilization implantation failure via openalex
Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity via openalex
Uterotubal transport disorder in adenomyosis and endometriosis--a cause for infertility via openalex
Who will benefit from uterus-sparing surgery in adenomyosis-associated subfertility? via openalex
W4295689030 via openalex
W1931597824 via openalex
W1967120925 via openalex
W1977958742 via openalex
W1990498979 via openalex
W2006494078 via openalex
W2020712773 via openalex
W2023586275 via openalex
W2033232788 via openalex
W2039585575 via openalex
W2049175197 via openalex
W2051150230 via openalex
W2058174458 via openalex
W2058228030 via openalex
W2072770901 via openalex
W2072840911 via openalex
W2097443687 via openalex
W2112159540 via openalex
W2112661893 via openalex
W2131074211 via openalex
W2133909395 via openalex
W2134101917 via openalex
W2135935849 via openalex
W2141987794 via openalex
W2145290390 via openalex
W2153757714 via openalex
W2173213419 via openalex
W2413704878 via openalex
W2513121273 via openalex
W2736858912 via openalex
W2753073405 via openalex
W2808401869 via openalex

Cited by (6)

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License: CC0 · commercial use OK

[1] Adenomyosis and infertility via openalex

[2] Adenomyosis and infertility: is there a causal link? via openalex

[3] Adenomyosis and infertility: the role of the junctional zone via openalex

[4] Adenomyosis: Impact on Fertility and Obstetric Outcomes via openalex

[5] Adenomyosis in infertile women: prevalence and the role of 3D ultrasound as a marker of severity of the disease via openalex

[6] An axonemal alteration in apical endometria of human adenomyosis via openalex

[7] Asymptomatic adenomyosis and embryo implantation in IVF cycles via openalex

[8] Attenuated monoamine oxidase a impairs endometrial receptivity in women with adenomyosis via downregulation of FOXO1† via openalex

[9] Cancer-Associated Mutations in Endometriosis without Cancer via openalex

[10] Clinical outcomes of infertility treatment for women with adenomyosis in Japan via openalex

[11] Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium via openalex

[12] Conservative surgical management for diffuse uterine adenomyosis via openalex

[13] Conservative surgical treatment of adenomyosis to improve fertility: Controversial values, indications, complications, and pregnancy outcomes via openalex

[14] Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females via openalex

[15] Cytokine Profiling in the Eutopic Endometrium of Adenomyosis During the Implantation Window After Ovarian Stimulation via openalex

[16] Decreased Endometrial Expression of Leukemia Inhibitory Factor Receptor Disrupts the STAT3 Signaling in Adenomyosis During the Implantation Window via openalex

[17] Decreased Endometrial IL-10 Impairs Endometrial Receptivity by Downregulating HOXA10 Expression in Women with Adenomyosis via openalex

[18] Decreased Indian hedgehog signaling activates autophagy in endometriosis and adenomyosis via openalex

[19] Determining the Molecular Background of Endometrial Receptivity in Adenomyosis via openalex

[20] Diagnosing adenomyosis: an integrated clinical and imaging approach via openalex

[21] Diagnostic Accuracy of Transvaginal Ultrasound and Magnetic Resonance Imaging for Adenomyosis: Systematic Review and Meta-Analysis and Review of Sonographic Diagnostic Criteria via openalex

[22] Effect of pretreatment with a levonorgestrel-releasing intrauterine system on IVF and vitrified-warmed embryo transfer outcomes in women with adenomyosis via openalex

[23] Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis via openalex

[24] Endometrial L-selectin ligand is downregulated in the mid-secretory phase during the menstrual cycle in women with adenomyosis via openalex

[25] Expression of Inflammatory and Neurogenic Mediators in Adenomyosis via openalex

[26] Expression of integrin β3 and osteopontin in the eutopic endometrium of adenomyosis during the implantation window via openalex

[27] Expression of interleukin-8 and monocyte chemotactic protein-1 in adenomyosis via openalex

[28] Fertility outcome of infertile women with adenomyosis treated with the combination of a conservative microsurgical technique and GnRH agonist: long-term follow-up in a series of nine patients via openalex

[29] Fertility-Sparing Treatment of Adenomyosis in Patients With Infertility: A Systematic Review of Current Options via openalex

[30] Four subtypes of adenomyosis assessed by magnetic resonance imaging and their specification via openalex

[31] GnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity via openalex

[32] How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic via openalex

[33] HOXA10 expression is decreased in endometrium of women with adenomyosis via openalex

[34] Impaired decidualization of human endometrial stromal cells from women with adenomyosis† via openalex

[35] Infertility and adenomyosis via openalex

[36] Influence of controlled ovarian hyperstimulation on uterine peristalsis in infertile women via openalex

[37] Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of patients with adenomyosis during implantation window via openalex

[38] Long-term pituitary downregulation before frozen embryo transfer could improve pregnancy outcomes in women with adenomyosis via openalex

[39] Management of adenomyosis in subfertile women and pregnancy outcome via openalex

[40] Occurrence of chronic endometritis in different types of human adenomyosis via openalex

[41] Pituitary suppression before frozen embryo transfer is beneficial for patients suffering from idiopathic repeated implantation failure via openalex

[42] Pregnancy rate in women with adenomyosis undergoing fresh or frozen embryo transfer cycles following gonadotropin-releasing hormone agonist treatment via openalex

[43] Presence of adenomyosis at MRI reduces live birth rates in ART cycles for endometriosis via openalex

[44] Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent via openalex

[45] Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes via openalex

[46] Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis via openalex

[47] Reproductive Outcomes after Fertility-Sparing Surgery for Focal and Diffuse Adenomyosis: A Systematic Review via openalex

[48] Role of transvaginal sonography and magnetic resonance imaging in the diagnosis of uterine adenomyosis via openalex

[49] Scribble downregulation in adenomyosis compromises endometrial stromal decidualization by decreasing FOXO1 expression via openalex

[50] Serum Osteopontin Levels Are Decreased in Focal Adenomyosis via openalex

[51] Structural and molecular features of the endomyometrium in endometriosis and adenomyosis via openalex

[52] Surgery for Benign Gynecological Disorders Improve Endometrium Receptivity via openalex

[53] Surgical procedure to conserve the uterus for future pregnancy in patients suffering from massive adenomyosis via openalex

[54] Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group via openalex

[55] TGF-β1 Neutralization Improves Pregnancy Outcomes by Restoring Endometrial Receptivity in Mice with Adenomyosis via openalex

[56] The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure. II: adenomyosis and macrophages via openalex

[57] The Effect of Uterine Adenomyosis on IVF Outcomes: a Systematic Review and Meta-analysis via openalex

[58] The impact of adenomyosis on the outcome of IVF-embryo transfer via openalex

[59] Transcriptome analysis of eutopic endometrium in adenomyosis after GnRH agonist treatment via openalex

[60] Transcriptomics of receptive endometrium in women with sonographic features of adenomyosis via openalex

[61] Treatment of adenomyomectomy in women with severe uterine adenomyosis using a novel technique via openalex

[62] Uterine adenomyosis and in vitro fertilization outcome: a systematic review and meta-analysis via openalex

[63] Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations via openalex

[64] Uterine innervation in adenomyosis via openalex

[65] Uterine junctional zone at magnetic resonance imaging: a predictor of in vitro fertilization implantation failure via openalex

[66] Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity via openalex

[67] Uterotubal transport disorder in adenomyosis and endometriosis--a cause for infertility via openalex

[68] Who will benefit from uterus-sparing surgery in adenomyosis-associated subfertility? via openalex

[69] W4295689030 via openalex

[70] W1931597824 via openalex

[71] W1967120925 via openalex

[72] W1977958742 via openalex

[73] W1990498979 via openalex

[74] W2006494078 via openalex

[75] W2020712773 via openalex

[76] W2023586275 via openalex

[77] W2033232788 via openalex

[78] W2039585575 via openalex

[79] W2049175197 via openalex

[80] W2051150230 via openalex

[81] W2058174458 via openalex

[82] W2058228030 via openalex

[83] W2072770901 via openalex

[84] W2072840911 via openalex

[85] W2097443687 via openalex

[86] W2112159540 via openalex

[87] W2112661893 via openalex

[88] W2131074211 via openalex

[89] W2133909395 via openalex

[90] W2134101917 via openalex

[91] W2135935849 via openalex

[92] W2141987794 via openalex

[93] W2145290390 via openalex

[94] W2153757714 via openalex

[95] W2173213419 via openalex

[96] W2413704878 via openalex

[97] W2513121273 via openalex

[98] W2736858912 via openalex

[99] W2753073405 via openalex

[100] W2808401869 via openalex