Hormone receptors and enzymatic activities in human endometrial adenocarcinoma

S Dell'Acqua, Fiorenzo De Cicco Nardone, F de Cicco Nardone, M T Benedetto, Maria Teresa Benedetto, S Iacobelli, Stefano Iacobelli, F. Rossiello, Maurizio Bongiorno, M Bongiorno, Pasquale Alessandro Margariti, P A Margariti
Annals of the New York Academy of Sciences · 1990 · vol. 595(1) , pp. 334–347 · doi:10.1111/j.1749-6632.1990.tb34307.x · PMID:2142874 · W2051186373
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This study investigated hormone receptors and enzymatic activities in human endometrial adenocarcinoma to understand the relationship between receptor presence and therapy response.

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Abstract

The hormone sensitivity of endometrial carcinoma is related to the presence of steroid hormone receptors. The determination of progesterone receptors has been proposed in order to predict clinical prognosis and to aid treatment selection. The integrity of the hormone receptor system and postreceptoral events in tumors is essential to endocrine therapy response. Nevertheless, although hormone receptors are present in a large number of endometrial carcinomas, only 30% of cases respond to hormone therapy. In some neoplasms the receptors can be present, but not functioning, or else neoplastic transformation could have induced alterations in processes after hormone-receptor interaction.

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MeSH descriptors

Adenocarcinoma Receptors, Estrogen Receptors, Progesterone Uterine Neoplasms 17-Hydroxysteroid Dehydrogenases 17-Hydroxysteroid Dehydrogenases Adenocarcinoma Cell Nucleus Cell Nucleus Creatine Kinase Creatine Kinase Cytosol Cytosol Endometrium Endometrium Female Humans Interferon Type I Interferon Type I Medroxyprogesterone

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