Gamete intrafallopian transfer (GIFT) compared with intrauterine insemination in the treatment of unexplained infertility

Alison Murdoch; A P Murdoch; M. HARRIS; M. MAHROO; Margaret M. Williams; M Williams; W. Dunlop

doi:10.1111/j.1471-0528.1991.tb15362.x

Gamete intrafallopian transfer (GIFT) compared with intrauterine insemination in the treatment of unexplained infertility

Alison Murdoch, A P Murdoch, M. HARRIS, M. MAHROO, Margaret M. Williams, M Williams, W. Dunlop

British journal of obstetrics and gynaecology · 1991 · vol. 98(11) , pp. 1107–1111 · doi:10.1111/j.1471-0528.1991.tb15362.x · PMID:1760422 · W2103497066

RCT OA: closed CC0 ⤵ 4 in-corpus citations

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This trial found that gamete intrafallopian transfer (GIFT) yielded significantly higher pregnancy rates than intrauterine insemination (IUI) with or without ovarian hyperstimulation for unexplained infertility.

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Abstract

OBJECTIVE: To compare GIFT, intrauterine insemination (IUI) with, and without, ovarian hyperstimulation in the treatment of unexplained infertility. DESIGN: Women randomly allocated to one of three treatment protocols. SETTING: Northern Regional Fertility Centre. SUBJECTS: 59 couples with unexplained infertility of more than 3 years duration. INTERVENTIONS: Three cycles of either GIFT, IUI after ovarian hyperstimulation or IUI in a spontaneous cycle. MAIN OUTCOME MEASURES: Pregnancy resulting in a live birth. RESULTS: Fecundabilities were 0.12 after GIFT, 0.018 after ovarian hyperstimulation and IUI, and 0.018 after IUI in a spontaneous cycle. The fecundability after IUI was no different from that which would be expected without treatment in these couples but fecundability was significantly better (P greater than 0.02) after GIFT. CONCLUSIONS: This trial does not support the use of IUI in the treatment of unexplained infertility but confirms the value of GIFT.

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Condition tags

infertility

MeSH descriptors

Gamete Intrafallopian Transfer Infertility, Female Insemination, Artificial, Homologous Adult Chorionic Gonadotropin Chorionic Gonadotropin Female Fertility Humans Infertility, Female Infertility, Female Insemination, Artificial, Homologous Menotropins Menotropins Ovarian Follicle Ovarian Follicle Ovulation Induction Pregnancy

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Cited by (4)

References (10)

doi:10.1016/s0015-0282(16)59414-x via openalex
doi:10.1111/j.1471-0528.1991.tb13449.x via openalex
doi:10.1016/s0015-0282(16)44120-8 via openalex
W2415822213 via openalex
W2419261792 via openalex
W2616973505 via openalex
doi:10.1016/s0015-0282(16)47601-6 via openalex
doi:10.1016/s0015-0282(16)59825-2 via openalex
doi:10.1016/s0015-0282(16)48969-7 via openalex
doi:10.1016/s0140-6736(86)90621-5 via openalex

Cited by (4)

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[1] doi:10.1016/s0015-0282(16)59414-x via openalex

[2] doi:10.1111/j.1471-0528.1991.tb13449.x via openalex

[3] doi:10.1016/s0015-0282(16)44120-8 via openalex

[4] W2415822213 via openalex

[5] W2419261792 via openalex

[6] W2616973505 via openalex

[7] doi:10.1016/s0015-0282(16)47601-6 via openalex

[8] doi:10.1016/s0015-0282(16)59825-2 via openalex

[9] doi:10.1016/s0015-0282(16)48969-7 via openalex

[10] doi:10.1016/s0140-6736(86)90621-5 via openalex