Evidence that chorion-decidual prolactin release is calcium dependent

S R Richards, Stephen R. Richards, M H Kim, Moon H. Kim, W B Malarkey, William B. Malarkey
The Journal of clinical endocrinology and metabolism · 1982 · vol. 54(4) , pp. 820–823 · doi:10.1210/jcem-54-4-820 · PMID:7061690 · W2048534119
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Chorion-decidual prolactin release is regulated by extracellular calcium, with lower calcium decreasing release and added calcium increasing release, suggesting calcium dependence.

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Abstract

The regulation of PRL release from chorion-decidual explants was evaluated in organ cultures. Agents previously shown to stimulate pituitary release in vitro (TRH, theophylline, estradiol, and vasoactive intestinal polypeptide) were all without effect on chorion-decidual PRL release. Media free of calcium, however, resulted in 44% decreased chorion-decidual PRL release. Conversely, 2.5 mM CaCl2 produced a 64% increase in PRL release (P less than 0.01). Also, calcium chelation with EGTA (0.125-1.0 mM) produced a dose-related decrease in chorion-decidual PRL release. This decrease was greatest at 1.0 mM (P less than 0.01), being 56% of control. In contrast, the calcium-calmodulin complex inhibitor trifluoperazine (10 micrometers) did not significantly alter chorion-decidual PRL release. These studies and previous report in the literature suggest that different control mechanisms govern pituitary and chorion-decidual PRL release; however, an exception appears to be a common role for calcium.

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MeSH descriptors

Calcium Chorion Decidua Prolactin Calcium Chorion Chorion Cycloheximide Cycloheximide Decidua Decidua Female Humans Organ Culture Techniques Pregnancy Prolactin

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