The results of in vitro fertilization-embryo transfer in couples with unexplained infertility failing to conceive with superovulation and intrauterine insemination

Timur Gürgan, T Gürgan, Bülent Urman, B Urman, H Yarali, Hakan Yaralı́, Hüsnü A. Kişnişçi, H A Kişnişçi
Fertility and sterility · 1995 · vol. 64(1) , pp. 93–97 · doi:10.1016/s0015-0282(16)57661-4 · PMID:7789586 · W2406441027
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This study investigated the outcomes of in vitro fertilization-embryo transfer in couples with unexplained infertility who had previously failed to achieve pregnancy with superovulation and intrauterine insemination.

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Abstract

OBJECTIVE: To determine the results of IVF-ET in couples with long-standing unexplained infertility who had failed to conceive with four to six cycles of superovulation and IUI. DESIGN: Retrospective case control series. SETTING: University IVF-ET center. PATIENTS: One hundred seventeen couples with unexplained infertility who had failed to conceive with superovulation and IUI underwent 157 cycles of IVF-ET. Results were compared with 194 tubal factor couples subjected to 250 IVF-ET cycles within the same time period. RESULTS: Total fertilization failure events were more common (20.4% versus 7.6%) and tended to be repetitive in couples with unexplained infertility. When total fertilization failure events were excluded, fertilization rates (57.8% versus 60.9%) and cumulative clinical pregnancy rates over three cycles (55.4% versus 46.5%) were similar in unexplained infertility and tubal disease groups. CONCLUSIONS: Couples with unexplained infertility failing to conceive with superovulation and IUI have a favorable outcome when treated subsequently with IVF-ET. Conception rates similar to couples with tubal disease may be expected despite a higher incidence of total fertilization failure events.

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Condition tags

infertility

MeSH descriptors

Embryo Transfer Fertilization in Vitro Infertility Pregnancy Adult Fallopian Tubes Female Humans Infertility Infertility, Female Infertility, Female Insemination, Artificial, Homologous Male Retrospective Studies Superovulation Treatment Failure

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