Production of 12-hydroxyeicosatetraenoic acid in early pregnant uterine cervix--lack of correlation to mifepristone-induced cervical ripening. A double-blind randomized biomechanical and biochemical study

Katarina Heidvall, K Heidvall, A. Radestad, Joselyn Lindgren, N J Christensen, Angelique Flöter Rådestad, Niels Juel Christensen, J A Lindgren
Prostaglandins · 1992 · vol. 43(5) , pp. 473–482 · doi:10.1016/0090-6980(92)90129-h · PMID:1584996 · W1606764860
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Cervical biopsies from women undergoing first-trimester abortion produced 12-HETE and leukotrienes, but these metabolites showed no correlation with mifepristone-induced cervical ripening.

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Abstract

The regulation of cervical ripening in pregnancy may involve arachidonic acid metabolites. We studied the formation of lipoxygenase products in cervical biopsies from twenty nulliparous women requesting a first trimester abortion. The patients were randomly allocated to receive either 100 mg of the progesterone antagonist mifepristone (RU 486) or placebo 48 and 36 hours before surgery. A capacity to produce significant amounts of 12-HETE and material co-chromatographing with leukotrienes was observed in the cervical tissue. No qualitative or quantitative relationship to mifepristone-induced cervical ripening was found. Although our data suggest a large variation of 12-HETE production it remains to clarify its role in the cervix.

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MeSH descriptors

Cervix Uteri Cervix Uteri Hydroxyeicosatetraenoic Acids Mifepristone Pregnancy Trimester, First 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Abortion, Induced Adult Cervix Uteri Cervix Uteri Double-Blind Method Female Humans Hydroxyeicosatetraenoic Acids In Vitro Techniques Lipoxygenase Lipoxygenase Mifepristone Pregnancy Pregnancy Trimester, First

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