Decreased bone mineral density during GnRH analog therapy and polymorphism of estrogen receptor gene in precocious puberty

Y Nakayama, Yuko Nakayama, Rieko Tadokoro‐Cuccaro, R Tadokoro, O Arisaka, Osamu Arisaka, Akifumi Tokita, A Tokita, Yuichiro Yamashiro, Y Yamashiro
Endocrine journal · 1999 · vol. 46(Suppl) , pp. S55–S57 · doi:10.1507/endocrj.46.suppl_s55 · PMID:12054121 · W1987780247
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This study investigated the relationship between decreased bone mineral density during GnRH analog therapy and estrogen receptor gene polymorphism in children with precocious puberty.

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Abstract

plays an important role in bone maturation and bone mineralization during puberty We previously reported that bone mineral accretion was not adversely affected by short time

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MeSH descriptors

Bone Density Buserelin Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Leuprolide Puberty, Precocious Receptors, Estrogen Bone Density Buserelin Child Child, Preschool Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Leuprolide Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Puberty, Precocious Puberty, Precocious

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License: CC0 · commercial use OK