Concentration effect of prostaglandin E2 on the growth factor expression and cell proliferation in bovine endometrial explants and their kinetic characteristics

S Zhang, W Mao, W. F. Mader, Q Li, Ruifeng Gao, R Gao, Y Zhang, Yuanyuan Zhang, Long Gao, L Gao, C Fu, Changqi Fu, Jindi Wu, J Wu, Yang Deng, Y Deng, Y Shen, Yuan Shen, T Li, B. Liu, Bo Liu, Jinshan Cao
Reproduction in domestic animals = Zuchthygiene · 2017 · vol. 53(1) , pp. 143–151 · doi:10.1111/rda.13083 · PMID:29080298 · W2766044169
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Prostaglandin E2 at concentrations of 10⁻⁷ to 10⁻⁵ M up-regulated growth factor expression and induced proliferation while reducing apoptosis in bovine endometrial explants in vitro.

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Abstract

Bovine endometrium undergoes various physiological and histological changes that are necessary for blastocyst implantation during oestrous cycle. From pro-oestrus to late-oestrus, endometrium thickens gradually for implantation preparation and exhibits remarkable capacity for self-repair after uterine lining shedding while implantation does not occur. The prostaglandin E2 (PGE2 ) secretion pattern is synchronized with endometrial growth during oestrous cycles in bovine endometrium; however, limited information is available regarding the association between PGE2 secretion and endometrial growth. In this study, the concentration (10-9 to 10-5  M) and time effect (2-36 hr) of PGE2 treatment on a series of growth factors are essential for endometrial growth including connective tissue growth factor (CTGF), fibroblast growth factor-2 (FGF-2), interleukin-8 (IL-8), transforming growth factor-β1 (TGF-β1), matrix metalloproteinase-2 (MMP-2), and vascular endothelial growth factor A (VEGFA) mRNA and protein expression, and proliferation of epithelial and fibroblast cells was investigated in bovine endometrial explants in vitro. The results indicated that PGE2 at concentration about 10-7 to 10-5  M could up-regulate CTGF, FGF-2, IL-8, MMP-2, TGF-β1, VEGFA mRNA and protein expression, and could induce the proliferation of epithelial and fibroblast cells and reduce the proapoptotic factor (caspase-3) expression in bovine endometrial explants in vitro. These results collectively improved the possibility of PGE2 functions in endometrial growth during oestrous cycles.

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MeSH descriptors

Cell Proliferation Dinoprostone Endometrium Intercellular Signaling Peptides and Proteins Animals Cattle Cell Proliferation Dinoprostone Endometrium Endometrium Estrous Cycle Estrous Cycle Female Intercellular Signaling Peptides and Proteins RNA, Messenger

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