Association between PTPN22 and endometriosis

Maria Ammendola, Ammendola M, Bottini N, Nunzio Bottini, Adalgisa Pietropolli, Saccucci P, Patrizia Saccucci, Fulvia Gloria-Bottini, Gloria-Bottini F
Fertility and sterility · 2008 · vol. 89(4) , pp. 993–4 · doi:10.1016/j.fertnstert.2007.04.008 · PMID:17624340
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

Female carriers of the PTPN22( *)T variant demonstrated significantly increased susceptibility to endometriosis compared to control individuals.

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Abstract

PTPN22 is currently one of the few known shared-autoimmunity genes and is therefore a candidate marker for endometriosis. Our data show that female carriers of the PTPN22( *)T variant are significantly more susceptible to endometriosis than controls.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Polymorphism, Genetic Polymorphism, Genetic Protein Tyrosine Phosphatase, Non-Receptor Type 22 Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Female Female Gene Frequency Gene Frequency Genetic Predisposition to Disease Genetic Predisposition to Disease Humans Humans Italy

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Source provenance

europepmc
last seen: 2026-10-23T06:08:06.940705+00:00
pubmed
last seen: 2026-10-08T21:04:31.715410+00:00
unpaywall
last seen: 2026-05-14T19:30:52.867331+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine