Endometriosis and adenomyosis: Similarities and differences

Jacques Donnez, Christina Anna Stratopoulou, Marie-Madeleine Dolmans, Marie‐Madeleine Dolmans
Best practice & research. Clinical obstetrics & gynaecology · 2023 · vol. 92 , pp. 102432 · doi:10.1016/j.bpobgyn.2023.102432 · PMID:38103509 · W4389328358
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This review summarizes current knowledge on deep endometriosis and adenomyosis, discussing their shared pathogenesis and symptoms, and exploring the possibility that they are differential phenotypes of the same disease.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This 2024 review examines deep endometriosis and uterine adenomyosis, describing how they affect about 200 million women worldwide and share similar histological patterns, pathogenic features, and symptoms. It summarizes current hypotheses that both conditions may originate from estrogen-dependent overproliferation of endometrial tissue followed by implantation in ectopic sites, while noting that neither disease’s pathogenesis has been fully elucidated and there are no efficient treatment options. The authors discuss the possibility that these two entities represent differential phenotypes of the same disease, with the main limitation being the ongoing lack of definitive mechanistic understanding. This paper is centrally about endometriosis and adenomyosis—specifically a comparative synthesis of shared mechanisms and whether deep endometriosis and uterine adenomyosis are related differential phenotypes.

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Endometriosis and adenomyosis: Similarities and differences. (2024) Bailliere’s Best Practice & Research: Clinical Obstetrics & Gynaecology — Vol. 92, p. 102432 [1-11] (2024) (2024) Bailliere’s Best Practice & Research: Clinical Obstetrics & Gynaecology — Vol. 92, p. 102432 [1-11] (2024) Open Access - Adobe PDF - 7.19 MB - Authors - Author Donnez, Jacques - Author Stratopoulou, Christina Anna UCLouvain - Author - Abstract - Deep endometriosis and uterine adenomyosis are two frequently encountered conditions affecting approximately 200 million women worldwide. They are closely related, showing similar histological patterns and multiple common pathogenic features, and share the same symptoms. It is therefore not surprising that they are often thought to have a common developmental origin. Indeed, both deep endometriosis and adenomyosis appear to derive from estrogen-dependent overproliferation of endometrial tissue and its subsequent implantation in ectopic sites. Although the scientific community has shown increasing interest in these diseases over recent years, neither pathogenesis has yet been elucidated, so there are currently no efficient treatment options. Understanding the mechanisms underlying disease development, as well as discerning their relationship, are key to improving clinical management for millions of patients. The aims of this review are to summarize current knowledge on deep endometriosis and adenomyosis pathogeneses and discuss the possibility that these two entities are actually differential phenotypes of the same disease. - Affiliations - APA - Chicago - FWB Donnez, J., Stratopoulou, C. A., & Dolmans, M.-M. (2024). Endometriosis and adenomyosis: Similarities and differences. Bailliere’s Best Practice & Research: Clinical Obstetrics & Gynaecology, 92, 102432 [1-11]. https://doi.org/10.1016/j.bpobgyn.2023.102432 (Original work published 2024)

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Condition tags

mesh:D004715endometriosisadenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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