Association of HLA-DPB1 gene with endometriosis in women of Guangdong Province in China

Yuan-li He, He YL, Yuanli He, Lili Zong, Li-Li Zong, Zong LL, Peng DX, Dong-Xian Peng, Liu ZH, Ze-Huan Liu, Zehuan Liu, Lin JH, Jiang-Hai Lin, Anlong Xu, An-Long Xu, Xu AL
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA · 2002 · vol. 22(5) , pp. 432–3 · PMID:12390706 · W2361365847
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This study genotyped HLA-DPB1 alleles in women with and without endometriosis and found no significant difference in allele frequencies, suggesting HLA-DPB1 is not associated with the condition.

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Abstract

OBJECTIVE: To analyze the hereditary susceptibility in patients with endometriosis by way of genotyping of HLA-DPB1 alleles. METHODS: The allelic types of HLA-DPB1 were detected by sequence-based typing (SBT) in 38 patients with endometriosis and 36 healthy women as the control. RESULT: Significant differences in the frequency of HLA-DRB1 allele was not observed between endometriotic patients and normal subjects. CONCLUSION: HLA-DPB1 allele may not be related to endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis HLA-DP Antigens Adult Adult Alleles Alleles China China Endometriosis Endometriosis Endometriosis Female Female Gene Frequency Gene Frequency HLA-DP Antigens HLA-DP Antigens HLA-DP beta-Chains HLA-DP beta-Chains Humans

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