Luoshi Neiyi Prescription inhibits estradiol synthesis and inflammation in endometriosis through the HIF1A/EZH2/SF-1 pathway

Lizheng Wu; Dan-Tong Lan; Dantong Lan; Bowen Sun; Rui Su; Fang-Li Pei; Fangli Pei; Zijun Kuang; Yixuan Su; Shu‐Hong Lin; Shuhong Lin; Xuanyin Wang; Siyuan Zhang; Xiaoxin Chen; Jinjin Jia; Cheng Zeng

doi:10.1016/j.jep.2024.118659

Luoshi Neiyi Prescription inhibits estradiol synthesis and inflammation in endometriosis through the HIF1A/EZH2/SF-1 pathway

Lizheng Wu, Dan-Tong Lan, Dantong Lan, Bowen Sun, Rui Su, Fang-Li Pei, Fangli Pei, Zijun Kuang, Yixuan Su, Shu‐Hong Lin, Shuhong Lin, Xuanyin Wang, Siyuan Zhang, Xiaoxin Chen, Jinjin Jia, Cheng Zeng

Journal of ethnopharmacology · 2024 · vol. 335 , pp. 118659 · doi:10.1016/j.jep.2024.118659 · PMID:39098622 · W4401305177

article OA: closed CC0 ⤵ 4 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Luoshi Neiyi Prescription inhibits estradiol synthesis and inflammation in endometriosis by targeting the HIF1A/EZH2/SF-1 pathway.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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References (67)

An international terminology for endometriosis, 2021, via openalex
Anti-mullerian hormone is expressed by endometriosis tissues and induces cell cycle arrest and apoptosis in endometriosis cells via openalex
Aromatase as a target for treating endometriosis via openalex
Aromatase inhibitors: the next generation of therapeutics for endometriosis? via openalex
Betulinic Acid Inhibits Endometriosis Through Suppression of Estrogen Receptor β Signaling Pathway via openalex
CD44 variant 6 is involved in the attachment and invasion of endometrial cells to peritoneum via openalex
Circulating miRNAs Related to Epithelial–Mesenchymal Transitions (EMT) as the New Molecular Markers in Endometriosis via openalex
Combination use of ferulic acid, ligustrazine and tetrahydropalmatine inhibits the growth of ectopic endometrial tissue: A multi-target therapy for endometriosis rats via openalex
Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis via openalex
Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis via openalex
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis via openalex
Effect of Luo′s neiyi recipe on the concentration of ICAM-1 and IL-8 in the peritoneal fluid cytology among the infertility patients with endometriosis. via openalex
Effect of Shixiao San on inflammatory factors and pain in rats with endometriosis via openalex
Endometriosis via openalex
Endometriosis and nuclear receptors via openalex
ESHRE guideline for the diagnosis and treatment of endometriosis via openalex
Estradiol promotes cells invasion by activating β-catenin signaling pathway in endometriosis via openalex
G protein–coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis via openalex
Hypoxia‐inhibited dual‐specificity phosphatase‐2 expression in endometriotic cells regulates cyclooxygenase‐2 expression via openalex
Hypoxia: The force of endometriosis via openalex
Impact of a Chinese Medicinal Formula, Xiao Liu Fang, on the “3A” Ability of Endometrial Stromal Cells in Patients with Endometriosis via openalex
Inhibition of transcription, expression, and secretion of the vascular epithelial growth factor in human epithelial endometriotic cells by romidepsin via openalex
Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis via openalex
Modified Gexiazhuyu decoction alleviates chronic salpingitis p38 signaling pathway. via openalex
Prevention of the recurrence of symptom and lesions after conservative surgery for endometriosis via openalex
Prostaglandin E2 Stimulates Aromatase Expression in Endometriosis-Derived Stromal Cells via openalex
Prostaglandin E <sub>2</sub> : the master of endometriosis? via openalex
Regulation of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Endometriotic Stromal Cells via openalex
Role of Estrogen Receptor-β in Endometriosis via openalex
SnapShot: Endometriosis via openalex
Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting via openalex
The effect of Bu Shen Huo Xue Tang on autoimmune premature ovarian insufficiency via Modulation of the Nrf2/Keap1 signaling pathway in mice via openalex
The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model via openalex
The Influence of Luoshi Neiyi Recipe on the Endometrial Morphology of Endometriosis Rat Model via openalex
The link between immunity, autoimmunity and endometriosis: a literature update via openalex
The Protective Role of Dexpanthenol on the Endometrial Implants in an Experimentally Induced Rat Endometriosis Model via openalex
Transactivation of Steroidogenic Acute Regulatory Protein in Human Endometriotic Stromal Cells Is Mediated by the Prostaglandin EP2 Receptor via openalex
Transcriptional Activation of Steroidogenic Factor-1 by Hypomethylation of the 5′ CpG Island in Endometriosis via openalex
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Cited by (4)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-05-26T00:32:29.469722+00:00

License: CC0 · commercial use OK

[1] An international terminology for endometriosis, 2021, via openalex

[2] Anti-mullerian hormone is expressed by endometriosis tissues and induces cell cycle arrest and apoptosis in endometriosis cells via openalex

[3] Aromatase as a target for treating endometriosis via openalex

[4] Aromatase inhibitors: the next generation of therapeutics for endometriosis? via openalex

[5] Betulinic Acid Inhibits Endometriosis Through Suppression of Estrogen Receptor β Signaling Pathway via openalex

[6] CD44 variant 6 is involved in the attachment and invasion of endometrial cells to peritoneum via openalex

[7] Circulating miRNAs Related to Epithelial–Mesenchymal Transitions (EMT) as the New Molecular Markers in Endometriosis via openalex

[8] Combination use of ferulic acid, ligustrazine and tetrahydropalmatine inhibits the growth of ectopic endometrial tissue: A multi-target therapy for endometriosis rats via openalex

[9] Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis via openalex

[10] Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis via openalex

[11] Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis via openalex

[12] Effect of Luo′s neiyi recipe on the concentration of ICAM-1 and IL-8 in the peritoneal fluid cytology among the infertility patients with endometriosis. via openalex

[13] Effect of Shixiao San on inflammatory factors and pain in rats with endometriosis via openalex

[14] Endometriosis via openalex

[15] Endometriosis and nuclear receptors via openalex

[16] ESHRE guideline for the diagnosis and treatment of endometriosis via openalex

[17] Estradiol promotes cells invasion by activating β-catenin signaling pathway in endometriosis via openalex

[18] G protein–coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis via openalex

[19] Hypoxia‐inhibited dual‐specificity phosphatase‐2 expression in endometriotic cells regulates cyclooxygenase‐2 expression via openalex

[20] Hypoxia: The force of endometriosis via openalex

[21] Impact of a Chinese Medicinal Formula, Xiao Liu Fang, on the “3A” Ability of Endometrial Stromal Cells in Patients with Endometriosis via openalex

[22] Inhibition of transcription, expression, and secretion of the vascular epithelial growth factor in human epithelial endometriotic cells by romidepsin via openalex

[23] Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis via openalex

[24] Modified Gexiazhuyu decoction alleviates chronic salpingitis p38 signaling pathway. via openalex

[25] Prevention of the recurrence of symptom and lesions after conservative surgery for endometriosis via openalex

[26] Prostaglandin E2 Stimulates Aromatase Expression in Endometriosis-Derived Stromal Cells via openalex

[27] Prostaglandin E <sub>2</sub> : the master of endometriosis? via openalex

[28] Regulation of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Endometriotic Stromal Cells via openalex

[29] Role of Estrogen Receptor-β in Endometriosis via openalex

[30] SnapShot: Endometriosis via openalex

[31] Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting via openalex

[32] The effect of Bu Shen Huo Xue Tang on autoimmune premature ovarian insufficiency via Modulation of the Nrf2/Keap1 signaling pathway in mice via openalex

[33] The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model via openalex

[34] The Influence of Luoshi Neiyi Recipe on the Endometrial Morphology of Endometriosis Rat Model via openalex

[35] The link between immunity, autoimmunity and endometriosis: a literature update via openalex

[36] The Protective Role of Dexpanthenol on the Endometrial Implants in an Experimentally Induced Rat Endometriosis Model via openalex

[37] Transactivation of Steroidogenic Acute Regulatory Protein in Human Endometriotic Stromal Cells Is Mediated by the Prostaglandin EP2 Receptor via openalex

[38] Transcriptional Activation of Steroidogenic Factor-1 by Hypomethylation of the 5′ CpG Island in Endometriosis via openalex

[39] VCAM-1 on Peritoneum and α4β1 Integrin in Endometrium and Their Implications in Endometriosis via openalex

[40] W2962434505 via openalex

[41] W1985473949 via openalex

[42] W1988304079 via openalex

[43] W2015132841 via openalex

[44] W2020676269 via openalex

[45] W2053421436 via openalex

[46] W2094051261 via openalex

[47] W2114570899 via openalex

[48] W2192202269 via openalex

[49] W2609369331 via openalex

[50] W2810127666 via openalex

[51] W2914562289 via openalex

[52] W2915976330 via openalex

[53] W936730092 via openalex

[54] W3002300448 via openalex

[55] W3007505839 via openalex

[56] W3014674233 via openalex

[57] W3063498583 via openalex

[58] W3091613651 via openalex

[59] W3207709525 via openalex

[60] W3214030520 via openalex

[61] W4283769499 via openalex

[62] W4316877121 via openalex

[63] W4324129757 via openalex

[64] W6606674401 via openalex

[65] W6646498800 via openalex

[66] W6810706467 via openalex

[67] W6814680148 via openalex