Differential expression of claudins in human endometrium and endometriosis

Regine Gaetje, R. Gaetje, Uwe Holtrich, Knut Engels, Stefan Kissler, Achim Rody, Thomas Karn, Manfred Kaufmann
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2008 · vol. 24(8) , pp. 442–449 · doi:10.1080/09513590802242694 · PMID:18850381 · W1989400324
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Researchers analyzed claudin expression in human endometrium and endometriosis, finding reduced claudin-3, -4, and -7 in ectopic endometrium, potentially contributing to cell detachment and invasion.

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Abstract

Membrane proteins of the claudin superfamily are important components of cellular tight and adherens junctions. Although their exact function remains unclear, these proteins may play a role in tissue remodeling, a process which is associated with several diseases including endometriosis. In the present work we analyzed the expression of 13 members of the claudin family in the endometrium and peritoneum by microarray analysis. Real-time polymerase chain reaction and immunohistochemistry in human endometrium and peritoneal endometriotic lesions were performed for validation of the expression of claudin-1, -3, -4, -5 and -7. Diminished expression of claudin-3, -4 and -7 in ectopic endometrium was frequently observed as indicated by all three methods. In contrast to a higher expression of claudin-5 mRNA detected in bulk biopsies of ectopic endometrium, immunohistochemistry revealed no alteration of claudin-5 protein expression in glandular cells of endometriosis samples. The downregulation of various members of the claudin family may contribute to endometrial cell detachment and increase the number of cells invading pelvic organs.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Profiling Membrane Proteins Adult Claudin-1 Endometriosis Endometriosis Endometrium Female Gene Expression Regulation Humans Membrane Proteins Membrane Proteins Menstrual Cycle Menstrual Cycle Menstrual Cycle Middle Aged Multigene Family Oligonucleotide Array Sequence Analysis

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