Stress, anxiety, and depression of both partners in infertile couples are associated with cytokine levels and adverse IVF outcome

Florina Haimovici, Janis L. Anderson, G. Wright Bates, Gordon W Bates, Catherine Racowsky, Elizabeth S. Ginsburg, Dan Simovici, Dan A. Simovici, Raina N. Fichorova
American journal of reproductive immunology (New York, N.Y. : 1989) · 2018 · vol. 79(4) , pp. e12832 · doi:10.1111/aji.12832 · PMID:29528174 · W2791454035
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In 45 infertile couples undergoing IVF, partner stress and psychiatric disorders correlated with altered cytokine levels in serum and reproductive fluids, predicting lower clinical pregnancy and live birth rates.

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Abstract

PROBLEM: Psychiatric disorders and stress in women have been associated with poor IVF outcome. We hypothesized that both partners in the infertile couples are emotionally affected, and cytokines in both may link psychological to reproductive outcome. METHOD OF STUDY: Forty-five IVF couples completed questionnaires and visual analog scales for stress and psychiatric disorders and had cytokines measured in serum, semen, cervicovaginal, and follicular fluids. Multivariable analyses, t tests, maximum likelihood estimates, Spearman correlation, and data mining were applied. RESULTS: Psychopathology was found in 72% of the couples. Female and male stress were associated with stress, anxiety, and depression in the respective partner, and with a lower likelihood of clinical pregnancy and live birth. Lower serum TGF-β and higher cervicovaginal IL-6 and IL-1β were associated with stress. In data decision trees, cytokines in relation to stress and depression in both partners were found indicative of IVF failure. CONCLUSION: Infertile couples may benefit from psychiatric evaluation and treatment of both partners.

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MeSH descriptors

Anxiety Depression Fertilization in Vitro Infertility Stress, Psychological Adult Anxiety Anxiety Cytokines Cytokines Depression Depression Female Fertilization in Vitro Humans Infertility Infertility Infertility Inflammation Mediators Inflammation Mediators

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