No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis

Emma Robertson, E Robertson, Ian Jones, I Jones, Fiona Middle, F Middle, J. Moray, N. Craddock
Acta psychiatrica Scandinavica · 2003 · vol. 108(5) , pp. 387–391 · doi:10.1034/j.1600-0447.2003.00167.x · PMID:14531760 · W2032270466
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Genotyping 242 women with bipolar disorder revealed no association between 5HT2A gene polymorphisms and bipolar affective puerperal psychosis, indicating these variants do not play a major role in its development.

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Abstract

OBJECTIVE: To examine whether variation at two common polymorphisms, T102C and -1438AG, of the serotonin 2A gene (5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis. METHOD: A total of 242 parous women diagnosed with bipolar disorder were genotyped for the two polymorphisms. Of these, 165 women had experienced a manic or psychotic episode, according to DSM-IV criteria, within 6 weeks of childbirth (the puerperal psychosis group). The comparison group comprised of 77 parous women who had not experienced psychiatric disturbance following childbirth. RESULTS: No significant differences between genotype or allelic frequencies were found between the two groups for either polymorphism. CONCLUSION: The results indicate that variation at two common polymorphisms of the 5HT2A gene does not appear to play a major role in the development of bipolar affective puerperal psychosis.

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MeSH descriptors

Bipolar Disorder Polymorphism, Genetic Puerperal Disorders Receptor, Serotonin, 5-HT2A Adult Alleles Bipolar Disorder Bipolar Disorder Bipolar Disorder Female Gene Frequency Genotype Humans Polymorphism, Genetic Psychotic Disorders Psychotic Disorders Psychotic Disorders Psychotic Disorders Puerperal Disorders Puerperal Disorders

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