Quality of life associated to chronic pelvic pain is independent of endometriosis diagnosis-a cross-sectional survey

Carlos A Souza, Carlos Augusto Bastos de Souza, Luciano Machado de Oliveira, Luciano M Oliveira, Camila Scheffel, Vanessa K Genro, Vanessa Krebs Genro, Virginia Rosa, Virgínia de Oliveira Rosa, Marcia F Chaves, Márcia Lorena Fagundes Chaves, João Sabino Cunha‐Filho, João S Cunha Filho
Health and quality of life outcomes · 2011 · vol. 9(1) , pp. 41 · doi:10.1186/1477-7525-9-41 · PMID:21663624 · W2151245760
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This study found that higher chronic pelvic pain scores negatively correlate with psychological and environmental quality of life, but endometriosis diagnosis does not further impact these scores.

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This cross-sectional survey studied 57 women aged 25–48 who underwent laparoscopy for chronic pelvic pain (CPP), assessing pain intensity via a visual analogue scale and quality of life using the WHOQOL-bref across physical, psychological, social, and environmental domains, along with anxiety and depressive symptoms. Women with higher CPP pain scores had lower quality of life specifically in the psychological and environmental domains, with psychological domain scores negatively correlated with pain intensity. When stratified by laparoscopy findings, quality of life scores were similar between women with endometriosis and those with other causes of pelvic pain, with all endometriosis cases classified as minimal and mild. The study’s limitation is its cross-sectional design and its restriction of endometriosis to minimal/mild disease when evaluating diagnosis-related differences. This paper is centrally about endometriosis — it tests whether having endometriosis (vs other CPP causes) adds additional impact on quality of life in women with chronic pelvic pain.

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Abstract

BACKGROUND: Pain is strongly related to poor quality of life. We performed a cross-sectional study in a university hospital to investigate quality of life in women suffering from chronic pelvic pain (CPP) due to endometriosis and others conditions. METHODS: Fifty-seven patients aged between 25 and 48 years-old submitted to laparoscopy because of CPP were evaluated for quality of life and depressive symptoms. Quality of life was accessed by a quality of life instrument [World Health Organization Quality of Life Assessment-Bref (WHOQOL-bref)]. Causes of pelvic pain were determined and severity of CPP was measured with a visual analogue scale. According to the intensity of pelvic pain score, patients were classified in two groups (group Low CPP 25th percentile). Four dimensions on quality of life were measured (physical, psychological, social and environmental). We stratified the analysis of quality of life according CPP causes (presence or not of endometriosis in laparoscopy). RESULTS: Patients with higher pain scores presented lower quality of life status in psychological and environmental dimensions. We found a negative correlation between pain scores and psychological dimension of quality of life (r = -0.310, P = .02). Quality of life scores were similar between groups with and without endometriosis (physical 54.2 ± 12.8 and 51.1 ± 13.8, P = 0.504; psychological 56.2 ± 14.4 and 62.8 ± 12.4, P = 0.182; social 55.6 ± 18.2 and 62.1 ± 19.1, P = 0.325; environmental 59.2 ± 11.7 61.2 ± 10.8, P = 0.608; respectively) CONCLUSIONS: Higher pain scores are correlated to lower quality of life; however the fact of having endometriosis in addition to CPP does not have an additional impact upon the quality of life.
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Abstract

Background: Pain is strongly related to poor quality of life. We performed a cross-sectional study in a universitary hospital to investigate quality of life in women suffering from chronic pelvic pain (CPP) due to endometriosis and others conditions.

Methods

Fifty-seven patients aged between 25 and 48 years-old submitted to laparoscopy because of CPP were evaluated for quality of life and depressive symptoms. Quality of life was accessed by a quality of life instrument [World Health Organization Quality of Life Assessment-Bref (WHOQOL-bref)]. Causes of pelvic pain were determined and severity of CPP was measured with a visual analogue scale. According to the intensity of pelvic pain score, patients were classified in two groups (group Low CPP 25th percentile). Four dimensions on quality of life were measured (physical, psychological, social and environmental). We stratified the analysis of quality of life according CPP causes (presence or not of endometriosis in laparoscopy).

Results

Patients with higher pain scores presented lower quality of life status in psychological and environmental dimensions. We found a negative correlation between pain scores and psychological dimension of quality of life (r = -0.310, P = .02). Quality of life scores were similar between groups with and without endometriosis (physical 54.2 ± 12.8 and 51.1 ± 13.8, P = 0.504; psychological 56.2 ± 14.4 and 62.8 ± 12.4, P = 0.182; social 55.6 ± 18.2 and 62.1 ± 19.1, P = 0.325; environmental 59.2 ± 11.7 61.2 ± 10.8, P = 0.608; respectively)

Conclusions

Higher pain scores are correlated to lower quality of life; however the fact of having endometriosis in addition to CPP does not have an additional impact upon the quality of life.

Keywords

chronic pelvic pain, endometriosis, depression, anxiety, quality-of-life

Background

Chronic pelvic pain (CPP) can be defined as a nonmalig- nant pain perceived in structures related to the pelvis; constant or recurring over a period of 6 months. In some cases it might be associated with negative cognitive, behavioral and social consequences [1]. The prevalence of CPP is variable according to the studied population; a populational study have demonstrated a rate of 3.8% [2], however in infertility samples this rate could be as high as 40% [3]. CPP is an important burden in women of reproductive age, with a direct impact on their marital, social and professional life [4,5]. Several papers with dif- ferent methodological characteristics have shown an association of CPP with a negative impact on personal activities [6-8]. Endometriosis is a benign disease that mainly affects females during reproductive years and it is strongly asso- ciated with pelvic pain, being the most common gynaeco- logical cause of CPP [9]. The strong association between endometriosis and pelvic pain was already demonstrated [10] and a discussion on nerve involvement as a factor contributing to pelvic pain in deep infiltrating endometrio- sis (DIE) has been published [9]. Although the physio- pathology of pelvic pain in patients with endometriosis is * Correspondence: [email protected] 1Serviço de Ginecologia e Obstetrícia, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brasil Full list of author information is available at the end of the article Souza et al . Health and Quality of Life Outcomes 2011, 9:41 http://www.hqlo.com/content/9/1/41 © 2011 Souza et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. still speculative, several clin ical trials have documented that the treatment of endometriosis in these patients reduces associated symptoms [9,10]. Women with endo- metriosis presented more severe pain and greater social dysfunction than those with unexplained pain [11]. In addition, the proper treatment of endometriosis increases the quality of life and improves social behavior in this population [12]. Recently, authors have demonstrated that quality of life and sexual satisfaction of patients with CPP and endometriosis is altered [8]. Patients with CPP suffer from different pain intensi- ties, and an important point is if patients with more intense pain have greater al teration in quality of life [7,13]. Others causes of CPP are also associated to alterations in perception of quality of life [13,14]. How- ever, until this moment the complex relationship between the several causes of CPP and quality of life were not completely evaluated and questions remain unsolved. The aim of this study was to evaluate the influence of CPP on the quality of life and evaluate if endometriosis diagnosis per se adds a negative effect in patients’ quality of life.

Methods

Design We performed a cross-sectional study between April 2006 and December 2008. Patients We included 66 consecutive patients complaining of pelvic pain aged between 25 and 48 years-old in the study. We defined pelvic pain as dysmenorrhoea and/or intermenstrual pelvic pain and/or dyspareunia of moder- ate to severe intensity lasting for more than 6 months [15]. We excluded patients w ith malignancies diagnosis (1), uterine myomas (2), ovarian cists (3), inflammatory pelvic disease (1), and pregnancy (2), so our final study population was 57 patients. The study was approved by the Ethical Committee of Hospital de Clínicas de Porto Alegre (IRB) and informed consent was obtained from all patients. Data collection One month before laparoscopy, we collected baseline information (Age, gravity, vaginal labor, cesarean section, abortion and time of forma l education), and patients answered an inventory about pelvic pain intensity. We interviewed all patients in or der to evaluate: cognitive impairment, quality of life, anxiety symptoms, and depres- sive symptoms. After this initial evaluation, all patients were submitted to laparoscopy for pelvic pain investigation by the same investigator (JSLC). None of the patients had used oral contraceptives, progestagens, antinflamatory, antidepressives or psychotropic formulations in the three months that preceded the laparoscopy or Gonadotropin Releasing Hormone (GnRH) analogues in the last six months. Non-gynecologic causes of pelvic pain were excluded in all patients using history, physical examination and laboratory exams when appropriate. Instruments The Visual Analogue Scale (VAS) was used to measure the mean pain intensity over the last three days (average for rest and activity). The 10-cm scale was marked with ‘’0’’ (no pain) and ‘’10’’ (worst possible pain), and the patients were instructed on how to use the scale [11]. Since CPP and endometriosis are two burden chronic diseases we chose to evaluate cognitive impairment in all patients. The exclusion of cognitive impairment was done using the Mini Mental State Examination (MMSE) [16,17]. Quality of life was accessed by quality of life instrument [World Health Organization Quality of Life Assessment-Bref (WHOQOL-bref)], in an adequate translated and validated version [18]. It is a brief 26-item questionnaire, including 2 items for general quality of life and health status and another 24 items categorized into 4 domains (physical, psychological, social, and environmen- tal). The item scores range from 1 to 5, with the higher score indicating the better quality of life on the corre- sponding item. The score for each domain ranges from 4 to 20, which is obtained by multiplying the average score of all items in this domain by the same factor of 4 [18]. Anxiety was evaluate by the The Hamilton Anxiety Rating Scale (HARS) [19]. The Brazilian version of the scale has showed to be reliable and valid, including 14 items on both physical and psychological symptoms [19]. Finally, depression was evaluated by the Beck Depression Inventory (BDI). The revised BDI is a 21-item self-assess- ment scale for eliciting severity of depression. Items score from 0 to 3. Reliability of internal consistency is good for mixed diagnoses as well as single and recurrent episode major depression [20]. The same investigator (LMO) applied all tests. Data analysis According to pain score (VAS) we classified patients in two groups: High CPP (> 25 th VAS percentile) and Low CPP (< 25 th VAS percentile). We compared epidemiologi- cal, anxiety symptoms, depressive symptoms and quality of life (physical, psychological, social and environmental) between the groups. We also calculated the correlation between pelvic pain intensity and quality of life in the four dimensions. After this initial analysis, we classified patients according to the cause of pelvic pain. Patients were desig- nated in two groups: endometriosis group and others ’ causes of pelvic pain group. The diagnosis of endometrio- sis was done using precise and standardized macroscopic criteria to make the visual dia gnosis [21]. Endometriosis Souza et al . Health and Quality of Life Outcomes 2011, 9:41 http://www.hqlo.com/content/9/1/41 Page 2 of 5 staging was carried out according to the classification of The American Society for Reproductive Medicine(ASRM) [22]. All statistics data were collected in a computerized database. Statistical analysis was performed using Statis- tical Package for the Social Sciences (SPSS) 13.0. The parametric data were presented as mean and mean stan- dard deviation. Student ’s t test was carried out when appropriate. Pearson co rrelation was determined between pain scores and quality of life. P-value < .05 was considered statistically significant for all compari- sons. The power of the study was calculated based on the following assumptions: (i) the sample size (n = 57), (ii) prevalence of endometriosis of 30% [23], (iii) expect difference of 8 points in each quality of life dimensions between the groups [24], (iv) type I and II errors of .05 and .19 respectively.

Results

At the time of inclusion women were aged 35.8 ± 8.6 years and they showed average pain scores of 5.9 ± 2.9 on a 10 point scale. High CPP × Low CPP Forty five patients presented pain scores consistent with the High CPP group (above the 75 th percentile) and 12 patients, with the Low CPP group (under the 25 th per- centile). Age, duration of formal education, parity, num- ber of vaginal deliveries and cesarean section remained similar irrespective of CPP groups (High and Low CPP). Unexpectedly, patients wit h High CPP demonstrated a lower number of abortions (1.2 ± 2.2 vs. 0.3 ± 0.7, P = .033) We observed a statiscally significant reduction in qual- ity life scores in patients classified in the High CPP group in the psychological (45.4 ± 15.6 vs. 58.2 ± 13.3, P = .007) and environmental (53.3 ± 10.7 vs.6 0 . 7± 10.9, P = .044) domains. Scores in the psychological dimension and VAS were negatively correlated (r = -0.31, P = .02). However, we failed to demonstrate any correlation of other quality life domains and VAS (phy- sical r = -0.078, P = .56; social r = -0.077, P = .573; and environmental r = -0.210, P = .104). The others vari- ables measured-MMSE and BDI scores-were similar between the two groups. Endometriosis × other ’s pelvic pain To clarify the role of endometriosis as a cause of CPP in quality of life scores patie nts were classified in two groups as stated by the cause of CPP diagnosed in laparoscopy: endometriosi s group (study group), 32 patients; and others ’ causes of pelvic pain group (control group), 25 patients. All endometriosis were classified as minimal and mild endometriosis. These two groups were similar according epidemiological characteristics (Additional file 1 Table 1). Further, the MMSE, the BDI and the HARS scores were not affected by the cause of CPP. Moreover, scores from the VAS were similar between patients with endometriosis (6.7 ± 1.6) and those with others causes of CPP (7.5 ± 1.6) (Additional file 2 Table 2). Physical, psychological, social and envir- onmental parameters of quality of life scale (WHOQOL- BREF) were similar between the groups.

Discussion

In this study, we demonstrated that the intensity of pelvic pain is inversely correlated w ith alteration in the quality of life of patients with CPP (higher scores of pelvic pain were associated to decrease in quality of life in two domains-psychological and environmental). Furthermore, we showed that the presence of endometriosis as a cause of CPP is not an independent factor for modifying quality of life in patients with CPP. Our study has some limitations: (i) all patients pre- sented minimal/mild endometriosis according to ASRM criteria. Probably it was a selection bias because our ser- vice is a referral centre of infertility treatment and patients with more severe CPP or pelvic masses might have been directed to other services. Although endome- triosis is an enigmatic disease and endometriosis classifi- cations have poor correlati on with clinical symptoms [25,26], patients with DIE or endometriomas could have presented more intense pain and differences in quality of life scores. This fact will remain to be elucidated since our sample does not contemplate these subjects. (ii) We compared patients with pelvic pain only, without the pre- sence of a disease-free control group. This fact could have affected our results. Conversely, this approach has permitted to verify the importance of the intensity of pain in quality of life. The strength of our study lies in the fact that we evaluated patients under evaluation for CPP and use tools common to other forms of CPP and not only specific instruments for endometriosis. We decided not to use a specific instrument, described pre- viously [7], to measure quality of life for patients with endometriosis because this would have introduced signif- icant bias since our sample was also composed of patients without endometriosis [8]. Therefore, we have used an instrument that applies for all pelvic pain patients-the major resourc e of our investigation. Our

Results

were, consequently, more comparable to other studies, and are in agreement with the results from authors that did not show any difference in terms of mood symptoms or personality characteristics when patients with endometriosis and unexplained pelvic pain were compared [11]. Authors showed that patients with chronic pelvic pain present some degree of hyperalgesia and some impairment Souza et al . Health and Quality of Life Outcomes 2011, 9:41 http://www.hqlo.com/content/9/1/41 Page 3 of 5 of quality of life parameters (physical and mental) mea- sured by SF-36 instrument [7]. Furthermore, these authors verified an increment in the intensity of pelvic pain in association with deterioration of quality of life. Unfortu- nately, we were not able to de monstrate differences in quality of life scores in all dimensions, only in psychologi- cal and environmental. Perhaps if we increase the number of patients in our groups we could be able to show this difference in all quality of life dimensions. Others, in a sys- tematic review, demonstrated that mental health was the area of health-related quality of life that was most nega- tively affected by chronic pelvic pain whereas the least affected area was physical activities [6]. In addition, when pelvic pain is a primary symptom of gynecological dis- eases, like endometriosis it appears to have an even greater negative impact on health-related quality of life as com- pared to those conditions in which pelvic pain is not the most important symptom. As a distinctiveness of our paper, we investigated the effect of endometriosis itself in quality of life of patients that presented with CPP. Pain is one of the major con- cerns of patients with endometriosis and its effect upon quality of life has been already shown [27] and we demonstrated that quality of life status was not affected by endometriosis per se . Infertility is another important characteristic of endometriotic patients. Although the number of pregnancies between the groups (endome- triosis and without endometriosis) seems to be similar between the groups with, we can consider the possibility that infertility associated to endometriosis can also mod- ify patients ’ quality of life. Authors have already demon- strated the diagnosis delay in endometriosis patients that suffer only from pain is almost twice the period of diagnosis for patients with infertility [25]. In accordance to our findings, a plethora of publica- tions have shown that patients with chronic pelvic pain have a decreased quality of life and, consequently, reduced social adjustment with an increase in psychia- tric morbidity [6,28], and rece ntly alterations in sexual life [8]. Our data indicates that alterations in patient ’s quality of life are independent of the presence of endo- metriosis and they are in agreement with other authors that have demonstrated that CPP patients with or with- out endometriosis have no difference in results from quality of life and sexual life inventories [8]. The high prevalence of symptoms of anxiety and depression observed in both groups of this investigation was sub- stancial. However, this finding was expected and consis- tent because our sample included only patients suffering from chronic pelvic pain. Moreover, it is important to emphasize that one of our objectives was to investigate the role of endometriosis in addition to pelvic pain as a determinant factor for quality of life [29,30].

Conclusions

In conclusion, we showed that the cause of pelvic pain does not influence the quality of life status or anxiety- depression symptoms. Further, we demonstrated that pain intensity is correlated to a decrease in quality of life in psychological domain; and that patients with higher pelvic pain scores have lower quality of life in psychological and environmental dimensions. With this study we can speculate that management of pelvic pain of CPP patients, independent of the causal factor, is the best approach to improve quality of life of these patients. Additional material Additional file 1: Table 1 Additional file 2: Table 2 List of abbreviations (ASRM): American Society for Reproductive Medicine; (BDI): Beck Depression Inventory; (CPP): Chronic Pelvic Pain; (DIE): Deep Infiltrating Endometriosis; (GnRH): Gonadotropin Releasing Hormone; (IRB): Institutional Review Board; (MMSE): Mini Mental State Examination; (SPSS): Statistical Package for the Social Sciences; (HARS): The Hamilton Anxiety Rating Scale; (VAS): Visual Analogue Score; (WHOQOL-bref): World Health Organization Quality of Life Assessment-Bref.

Acknowledgements

We thank the FIPE-HCPA for the financial support. Author details 1Serviço de Ginecologia e Obstetrícia, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brasil. 2Serviço de Neurologia, Hospital de Clinicas de Porto Alegre, UFRGS, Porto Alegre, Brasil. 3Departamento de Ginecologia e Obstetrícia, Universidade Federal do Rio Grande do Sul Porto Alegre, Brasil. Authors’ contributions CAS, LMO, JSL conceived and designed the study. CAS and MC analysed and interpreted the data. JSL supervised and reviewed all the statistical analysis. VR, VG, CS, MC contributed to data collection and performed surgical procedures. All the authors contributed to write the manuscript. All the authors approved the final version of the manuscript. Competing interests The authors declare that they have no competing interests. Received: 3 April 2011 Accepted: 10 June 2011 Published: 10 June 2011

References

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Discussion

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Endometriosis Pelvic Pain Quality of Life Adult Anxiety Anxiety Chronic Disease Chronic Disease Cross-Sectional Studies Depression Depression Endometriosis Endometriosis Endometriosis Endometriosis Female Humans Laparoscopy Male Middle Aged

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