The influence of alpha-receptors on lordosis in the female rat
Lab / animal
OA: closed
CC0
⤵ 3 in-corpus citations
AI-generated summary
The alpha-adrenergic agonist clonidine suppressed lordosis in female rats, an effect blocked by yohimbine, suggesting distinct alpha-adrenergic receptor roles in the brain.
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Abstract
The alpha-adrenergic agonist clonidine suppressed lordotic responding in spayed female rats brought into heat by estrogen and progesterone. The suppression was blocked by the alpha-antagonist yohimbine, but not by phenoxybenzamine or pimozide. The suppression was blocked by the alpha-antagonist yohimbine, but not by phenoxybenzamine or pimozide. Phenoxybenzamine itself had no suppressive effect on lordosis, though yohimbine did under some conditions. These results argue against an important facilitatory influence of norepinephrine on lordosis in the rat. Further, in comparison with the quite different findings recently reported from the guinea pig, they offer support for the presence of two different kinds of alpha-adrenergic receptors in the brain with different physiological functions.
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Cites (1)
Cited by (3)
- Prevention of progesterone-induced lordosis behavior by alpha or beta adrenergic antagonists in ovariectomized estrogen-primed rats 1985
- Norepinephrine infusions into the medial preoptic area inhibit lordosis behavior 1986
- Biphasic effects of the antiserotonergic methysergide on lordosis in rats 1978
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Cited by (3)
- Norepinephrine infusions into the medial preoptic area inhibit lordosis behavior 1986
- Prevention of progesterone-induced lordosis behavior by alpha or beta adrenergic antagonists in ovariectomized estrogen-primed rats 1985
- Biphasic effects of the antiserotonergic methysergide on lordosis in rats 1978
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:06:07.402396+00:00
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- last seen: 2026-11-08T06:46:05.892536+00:00
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