5-Aminolevulinic acid photodynamic therapy and isotretinoin for treatment of drug-induced acne fulminans in a patient with idiopathic thrombocytopenic purpura

Jian-Chun Hao, Jianchun Hao, Tao Wang
Photodiagnosis and photodynamic therapy · 2019 · vol. 29 , pp. 101630 · doi:10.1016/j.pdpdt.2019.101630 · PMID:31870898 · W2994882685
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This paper reports the successful treatment of drug-induced acne fulminans in a patient with idiopathic thrombocytopenic purpura using 5-aminolevulinic acid photodynamic therapy combined with isotretinoin.

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Abstract

In this work, we present a case of deteriorative acne that occurred during methylprednisolone and danazol treatment of idiopathic thrombocytopenic purpura (ITP). Treatment of the patient with a combination of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and isotretinoin was satisfactory, though the patient had platelets as low as 4-10 × 109/L during treatment. We consider that the combination of oral isotretinoin and ALA-PDT was effective in this patient may be due to the synergetic effect of these treatments. To the best of our knowledge, no such cases have been reported.

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MeSH descriptors

Acne Vulgaris Aminolevulinic Acid Isotretinoin Photochemotherapy Photosensitizing Agents Purpura, Thrombocytopenic, Idiopathic Acne Vulgaris Acne Vulgaris Administration, Oral Adult Aminolevulinic Acid Danazol Danazol Drug Therapy, Combination Estrogen Antagonists Estrogen Antagonists Glucocorticoids Glucocorticoids Humans Isotretinoin

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SciLite annotations

chemicals 7
5-aminolevulinic acid isotretinoin prednisolone danazol 5-aminolevulinic acid isotretinoin isotretinoin

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License: CC0 · commercial use OK