Ovarian hyperstimulation-like syndrome after administration of triptorelin to a woman with endometriosis

Inaudi P, P. Inaudi, M. Mazzini, Mazzini M, G D'Aniello, G. D’Aniello, D'Aniello G, Trusso P, P. Trusso, Joghtapour A, A. Joghtapour, Petraglia F, F Petraglia, Felice Petraglia
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2002 · vol. 16(5) , pp. 403–405 · doi:10.1080/gye.16.5.403.405 · PMID:12587535 · W2104030494
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This report describes a rare case of ovarian hyperstimulation-like syndrome in a woman with endometriosis following a single dose of triptorelin, which resolved spontaneously.

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Abstract

Ovarian hyperstimulation after a single dose of gonadotropin-releasing hormone (GnRH) analog is a rare phenomenon. A case of ovarian hyperstimulation-like syndrome after sole administration of triptorelin (Decapeptyl 3.75 mg) is reported in a woman who had undergone surgery for an endometriotic cyst. After administration of the drug, abdominal pressure increased with nausea and diffuse pelvic pain. Ultrasound examination showed bilateral enlargement of the ovaries (right 74 x 62 mm, left 62 x 53 mm), more than 10 follicles ranging in diameter from 15-25 mm, proliferative endometrium 7 mm thick and fluid in the Douglas pouch up to 25 x 23 mm thick. Estradiol plasma level was in the normal range. The syndrome spontaneously resolved in the course of treatment and a spontaneous pregnancy occurred when the triptorelin effect disappeared.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Cysts Ovarian Hyperstimulation Syndrome Triptorelin Pamoate Adult Adult CA-125 Antigen CA-125 Antigen CA-125 Antigen Endometriosis Endometriosis Female Female Humans Humans Infertility, Female Infertility, Female Infertility, Female Infertility, Female Laparoscopy

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