Hsa-mir-135a Shows Potential as A Putative Diagnostic Biomarker in Saliva and Plasma for Endometriosis

Alexandra Perricos, Katharina Proestling, H Husslein, Lorenz Kuessel, Quanah J Hudson, René Wenzl, Iveta Yotova
Biomolecules · 2022 · vol. 12(8) , pp. 1144 · doi:10.3390/biom12081144 · PMID:36009038 · W4292546444
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Hsa-mir-135a was significantly elevated in the saliva and plasma of women with endometriosis, suggesting its potential as a noninvasive diagnostic biomarker for the condition.

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Abstract

Endometriosis is a chronic disease characterized by the implantation and proliferation of endometrial tissue outside of the uterine cavity. The nonspecific nature of the symptoms and the lack of sensitive, noninvasive diagnostic methods often lead to a significant delay in diagnosis, highlighting the need for diagnostic biomarkers. The correlation of circulating miRNAs with altered inflammatory signals seen in patients with endometriosis has raised the possibility that miRNAs can serve as biomarkers for the disease. In our study, we analyzed miRNA expression in saliva of women with and without endometriosis using a FireFly custom multiplex circulating miRNA assay. This focused panel included 28 human miRNAs, 25 of which have been previously found to be differentially expressed either in plasma, serum, and/or blood of women with endometriosis, compared to controls. We found that hsa-mir-135a was expressed significantly higher in the saliva of women with endometriosis, independent of disease stage and menstrual cycle phase. We confirmed that hsa-mir-135a also showed significantly elevated expression in the plasma of endometriosis patients. This indicates that hsa-mir-135a is a putative noninvasive biomarker of endometriosis in both saliva and plasma, but further validation studies are required to assess its clinical value as a biomarker.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Circulating MicroRNA Circulating MicroRNA Circulating MicroRNA Circulating MicroRNA Circulating MicroRNA Circulating MicroRNA Circulating MicroRNA Circulating MicroRNA Circulating MicroRNA Circulating MicroRNA Circulating MicroRNA Circulating MicroRNA Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (58)

Cited by (9)

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