Improved antibacterial function of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus

Jalal Ghaderkhani, Ghaderkhani J, Rasoul Yousefimashouf, Yousefimashouf R, Mohammadreza Arabestani, Arabestani M, Ghodratollah Roshanaei, Roshanaei G, Sara Soleimani Asl, Asl SS, Abbasalipourkabir R, Roghayeh Abbasalipourkabir
Artificial cells, nanomedicine, and biotechnology · 2019 · vol. 47(1) , pp. 1181–1193 · doi:10.1080/21691401.2019.1593858 · PMID:30942627
Lab / animal OA: closed CC-BY-4.0
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Abstract

The objective of this study was to assess the antibacterial activity of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus 544. Rifampicin-loaded solid lipid nanoparticles were prepared by a modified microemulsion/sonication method and characterized. The results showed the average size about 319.7 nm, PI about 0.20 and zeta potential about 18.4 mv, encapsulation efficacy and drug-loading were equal to 95.78 and 34.2%, respectively, with a spherical shape. Drug release lasted for 5 days. The antibacterial activity was statistically significant with p < .05 in bacterial and cell culture media compared to free Rifampicin. It can be concluded that solid lipid nanoparticles can be considered as a promising delivery system for improving the antibacterial activity of Rifampicin against Brucella abortus.

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MeSH descriptors

Anti-Bacterial Agents Anti-Bacterial Agents Brucella abortus Lipids Nanoparticles Rifampin Rifampin Animals Anti-Bacterial Agents Brucella abortus Cell Line Drug Carriers Drug Carriers Drug Liberation Hydrophobic and Hydrophilic Interactions Lipids Mice Microbial Sensitivity Tests Nanoparticles Particle Size

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pubmed
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License: CC-BY-4.0 · commercial use OK · attribution required
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