Insulin-like growth factor-I regulates vascular endothelial growth factor secretion by human oviductal epithelial cells and stromal fibroblasts

Kaei Nasu, Hiroko Itoh, Akitoshi Yuge, Yasushi Kawano, Hisashi Narahara
Journal of the Society for Gynecologic Investigation · 2006 · vol. 13(5) , pp. 368–371 · doi:10.1016/j.jsgi.2006.03.007 · PMID:16713312 · W2077233370
Lab / animal OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Insulin-like growth factor-I promotes vascular endothelial growth factor secretion from human oviductal epithelial cells and stromal fibroblasts.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: The aim of the current study is to evaluate the effect of insulin-like growth factor-I (IGF-I) on the production of vascular endothelial growth factor (VEGF) in the human fallopian tube. METHODS: Human oviductal epithelial cells (OEC) and oviductal stromal fibroblasts (OSF) were isolated from the ampullary segment of the fallopian tubes of six premenopausal patients in the proliferative phase of the menstrual cycle. The secretion of VEGF165 by cultured OEC and OSF in response to IGF-I was measured using an enzyme-linked immunosorbent assay (ELISA). RESULTS: The secretion of VEGF165 was detected in cultured OEC and OSF under untreated conditions. The secretion of VEGF165 was significantly stimulated with IGF-I administration in these cells. CONCLUSION: The present findings suggest that IGF-I in the local environment may stimulate oviductal vascular permeability by inducing the production of VEGF by oviductal cells through autocrine and paracrine mechanisms. The modulation of the VEGF production in the fallopian tube may contribute to the normal and pathologic processes of oviductal fluid secretion by regulating oviductal vascular permeability during the menstrual cycle and in the peri-implantation period.

My notes (saved in your browser only)

MeSH descriptors

Fallopian Tubes Insulin-Like Growth Factor I Vascular Endothelial Growth Factor A Adult Cells, Cultured Culture Media, Conditioned Culture Media, Conditioned Enzyme-Linked Immunosorbent Assay Epithelial Cells Epithelial Cells Epithelial Cells Fallopian Tubes Fallopian Tubes Female Fibroblasts Fibroblasts Fibroblasts Follicular Phase Humans Insulin-Like Growth Factor I

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (23)

Source provenance

openalex
last seen: 2026-05-10T10:48:03.114955+00:00
pubmed
last seen: 2026-10-08T21:03:44.483075+00:00
unpaywall
last seen: 2026-10-17T06:24:38.187582+00:00
License: CC0 · commercial use OK