Relationship of IL-6 ,TGF-β,matrix metalloproteinase-7 in peritoneal fluid and endometriosis

Qiumei Chen, Hua Guo, Yanping Huang
In: Zhongguo jiceng yiyao · 2013 · vol. 20(09) , pp. 1310–1312 · doi:10.3760/cma.j.issn.1008-6706.2013.09.015 · W3030373973
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IL-6, TGF-β, and MMP-7 levels were elevated in peritoneal fluid of endometriosis patients compared to controls, with IL-6 and MMP-7 concentrations increasing significantly in advanced stages.

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This study investigated the expression levels of interleukin-6, transforming growth factor-beta, and matrix metalloproteinase-7 in the peritoneal fluid of women with varying stages of endometriosis. Researchers analyzed samples from 35 control patients and 45 individuals diagnosed with stage I through IV disease using enzyme-linked immunosorbent assay techniques to determine concentration differences. The results demonstrated that concentrations of all three biomarkers were significantly higher in endometriosis patients compared to controls, with stage III and IV cases exhibiting even greater levels of IL-6 and MMP-7 than earlier stages. Additionally, the analysis revealed a significant positive correlation between IL-6 and MMP-7, while TGF-beta showed a negative correlation with MMP-7. This paper is centrally about endometriosis — specifically examining the role of inflammatory and proteolytic markers in peritoneal fluid across different disease stages.

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Abstract

Objective To evaluate the expression of IL-6,TGF-β,matrix metalloproteinase-7 (MMP-7) in the peritoneal fluid of different stage of endometriosis (EMs) patients.Methods Peritoneal fluid samples from female without EMs (n =35) and 45 patients with EMs (36 cases with stage Ⅰ,Ⅱ;9 cases with stage Ⅲ,Ⅳ)were obtained for detectionof IL-6,TGF-β,MMP-7byELISA.Results TheconcentrationofIL-6,TGF-β,MMP-7 was (736.5 ± 526.6) ng/L,(936.5 ± 523.5)ng/L and (5.63 ± 1.98) μg/L in EMs patients,which were higher than those in control group (P ＜ 0.01).The concentration of IL-6,MMP-7 was (948.6 ± 485.4) ng/L,(8.69 ± 1.23) μg/L in stage Ⅲ,Ⅳgroup,and (453.6 ± 256.8) rng/L,(4.23 ± 1.08) μg/L in stage Ⅰ,Ⅱ group,there were significant differences between the two groups (P ＜ 0.05).The concentration of MMP-7 was positively correlated with IL-6(r =0.789,P ＜0.01),and was negatively correlated with TGF-β(r =-0.458,P ＜0.05).Conclusion IL-6,TGF-β,MMP-7 may play roles in microecology immune imbalance and the development of EMs. Key words: Endometriosis ;  Peritoneal Lavge;  Matrixmetalloproteinases-7 ;  IL-6 ;  TGF-β
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腹腔液白介素-6、转化生长因子-β和基质金属蛋白酶-7与子宫内膜异位症的相关研究 Relationship of IL-6 ,TGF-β,matrix metalloproteinase-7 in peritoneal fluid and endometriosis 摘要目的 探讨腹腔液中白细胞介素-6 (IL-6)、转化生长因子-β(TGF-β)和基质金属蛋白酶-7(MMP-7)在不同r-AFS分期的子宫内膜异位症(EMs)患者腹腔液中的表达.方法 收集80例行腹腔镜检查及治疗的患者腹腔液,其中35例为无子宫内膜异位症的对照组,36例为子宫内膜异位症Ⅰ、Ⅱ期患者,9例为子宫内膜异位症Ⅲ、Ⅳ期的患者.采用双抗体夹心酶联免疫吸附(ELISA)法检测腹腔液中IL-6、TGF-β和MMP-9的浓度,并进行相关性分析.结果 子宫内膜异位症患者腹腔液中IL-6、TGF-β和MMP-7表达分别为(736.5±526.6) ng/L、(936.5±523.5) ng/L和(5.63±1.98) μg/L,明显高于对照组,差异均有统计学意义(均P＜0.01).子宫内膜异位症Ⅲ、Ⅳ期IL-6和MMP-7浓度分别为(948.6±485.4) ng/L、(8.69±1.23) μg/L,高于Ⅰ、Ⅱ期(453.6±256.8) ng/L、(4.23±1.08) μg/L,差异有统计学意义(均P＜0.05).IL-6与MMP-7的表达呈显著正相关(r =0.789,P＜0.01).TGF-β与MMP-7的表达呈显著负相关(r=-0.458,P＜0.05).结论 子宫内膜异位症患者腹腔液中IL-6、TGF-β、MMP-7可能导致腹腔微环境免疫失衡,并对子宫内膜异位症的发生发展起一定的促进作用. 更多相关知识 abstractsObjective To evaluate the expression of IL-6,TGF-β,matrix metalloproteinase-7 (MMP-7) in the peritoneal fluid of different stage of endometriosis (EMs) patients.Methods Peritoneal fluid samples from female without EMs (n =35) and 45 patients with EMs (36 cases with stage Ⅰ,Ⅱ;9 cases with stage Ⅲ,Ⅳ)were obtained for detectionof IL-6,TGF-β,MMP-7byELISA.Results TheconcentrationofIL-6,TGF-β,MMP-7 was (736.5 ± 526.6) ng/L,(936.5 ± 523.5)ng/L and (5.63 ± 1.98) μg/L in EMs patients,which were higher than those in control group (P ＜ 0.01).The concentration of IL-6,MMP-7 was (948.6 ± 485.4) ng/L,(8.69 ± 1.23) μg/L in stage Ⅲ,Ⅳgroup,and (453.6 ± 256.8) rng/L,(4.23 ± 1.08) μg/L in stage Ⅰ,Ⅱ group,there were significant differences between the two groups (P ＜ 0.05).The concentration of MMP-7 was positively correlated with IL-6(r =0.789,P ＜0.01),and was negatively correlated with TGF-β(r =-0.458,P ＜0.05).Conclusion IL-6,TGF-β,MMP-7 may play roles in microecology immune imbalance and the development of EMs. More相关知识 - 浏览0 - 被引4 - 下载0 相似文献 - 中文期刊 - 外文期刊 - 学位论文 - 会议论文

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