Vesical clear cell adenocarcinoma arising from endometriosis: A mullerian tumor, indistinguishable from ovarian clear cell adenocarcinoma

Eirwen M Miller, Ying Sun, I. M. Richardson, Ingride Richardson, Marina Frimer
Gynecologic oncology reports · 2016 · vol. 18 , pp. 8–10 · doi:10.1016/j.gore.2016.08.005 · PMID:27660815 · W2515792248
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This case report describes a vesical clear cell adenocarcinoma arising from endometriosis, sharing histological and immunohistochemical characteristics with ovarian clear cell adenocarcinoma of mullerian origin.

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Abstract

Endometriosis is associated with increased rates of ovarian, particularly clear cell, adenocarcinomas. Malignant transformation of ovarian endometriosis is most common but rare cases have been reported in the bladder, abdominal wall, diaphragm, and rectum. We present the case of a 44-year-old female with vesical clear cell adenocarcinoma arising in a background of endometriosis in the absence of other pelvic endometriosis. The malignancy was diagnosed on transurethral resection of bladder tumor and managed with radical surgery. Histology and immunohistochemical findings were consistent mullerian origin and indistinguishable from similar tumors arising in the female genital tract. Extrapolating from the gynecologic literature, the recommendation was made for adjuvant chemotherapy. Further studies are needed to clarify the optimal treatment paradigm for ovarian and bladder clear cell adenocarcinomas.

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endometriosis

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