Laparoscopic sclerotherapy for ovarian endometriomas during surgery for deep endometriosis: Outcomes of a 134‐patient cohort

Adrien Crestani, Benjamin Merlot, Paul-Henri Goualard, Paul‐Henri Goualard, C. Huet, Clothilde Huet, Zoé Husson, Zoe Husson, Thomas Dennis, Isabella Chanavaz-Lacheray, Isabella Chanavaz‐Lacheray, Horace Roman
International Journal of Gynecology & Obstetrics · 2025 · vol. 171(1) , pp. 431–437 · doi:10.1002/ijgo.70201 · PMID:40332134 · W4410159183
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Laparoscopic ethanol sclerotherapy for ovarian endometriomas combined with deep endometriosis resection was safe and achieved a 57% pregnancy rate and 16.5% recurrence over 23 months.

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Abstract

OBJECTIVE: To evaluate postoperative fertility outcomes and recurrence rates in patients undergoing laparoscopic ethanol sclerotherapy for endometriomas, combined with the resection of deep endometriosis lesions. METHODS: A retrospective cohort study was conducted at the Franco-European Multidisciplinary Endometriosis Institute (IFEMEndo), Clinique Tivoli-Ducos, Bordeaux, France. The study included 134 patients who underwent laparoscopic surgical resection of deep endometriosis lesions and ethanol sclerotherapy for endometriomas ≥40 mm, between October 2019 and September 2023. The procedure involved aspiration of cyst contents followed by 96% ethanol instillation. The main outcomes measured were fertility rates, endometrioma recurrence, anti-Müllerian hormone (AMH) levels, and postoperative complications. RESULTS: ). Severe postoperative complications occurred in 4.5% of patients, none attributed to ethanol sclerotherapy. After surgery, 78 patients expressed a desire to conceive and 45 (57%) achieved pregnancy, with 19 (42%) being spontaneous. The mean time to pregnancy was 13 ± 9 months. Cumulative pregnancy rates were 55.5% at 24 months and 78.8% at 36 months. Predictors of pregnancy included higher preoperative AMH levels (hazard ratio [HR] 1.35, P = 0.008) and absence of prior abdominal surgery (HR 0.32, P = 0.007). Recurrence of endometriomas was observed in 17 (16.5%) patients over a median follow-up of 23 months. CONCLUSION: In this cohort of patients treated with laparoscopic ethanol sclerotherapy during resection surgery for deep endometriosis, the procedure was safe, with satisfactory pregnancy and recurrence rates comparable to other ablative techniques.

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Condition tags

mesh:D004715endometriosisendometrioma

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

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