Impact of bupivacaine injection to trocar sites on postoperative pain following laparoscopic hysterectomy: Results from a prospective, multicentre, double-blind randomized controlled trial

İsmet Hortu, Ünal Türkay, Unal Turkay, Hasan Terzi, Ahmet Kale, Mehmet Yılmaz, Canan Balcı, Umit Aydın, Ümit Aydın, Antonio Simone Laganà
European journal of obstetrics, gynecology, and reproductive biology · 2020 · vol. 252 , pp. 317–322 · doi:10.1016/j.ejogrb.2020.07.007 · PMID:32653604 · W3040093222
RCT OA: closed CC0
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This randomized controlled trial investigated whether bupivacaine injection to trocar sites reduced postoperative pain after laparoscopic hysterectomy.

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Abstract

OBJECTIVES: Laparoscopic surgery has numerous advantages over open surgery in view of postoperative pain. In this context, to elevate its benefits and patient satisfaction, different pain management interventions have been used so far. This study aimed to evaluate the effect of bupivacaine injection to trocar sites following laparoscopic hysterectomy for the management of postoperative pain. STUDY DESIGN: In this study, patients were randomized into two groups (56 cases; 52 controls). A single injection of bupivacaine (0.5 %, 5 mg/mL) was introduced to trocar sites under subcutaneous tissue at a dose of 4 ml for the umbilicus and 2 ml for each 5-mm ancillary trocar site in the study group. No bupivacaine was administered to the control group. The primary aim was to measure differences in 2 -h postoperative numerical rating scale (NRS) pain scores between the two groups. The secondary aims were to evaluate differences between 1-, 4-, 6-, 24- and 48 -h postoperative NRS pain scores, surgical complications, estimated blood loss, duration of operation and analgesic consumption. RESULTS: The number of postoperative rescue doses of analgesics was found to be lower in the study group compared to the control group (median of 2 vs. 4; p < 0.01). The 1-, 4-, 6-, 24- and 48-hour postoperative NRS pain scores were also found to be lower in the study group compared to the control group (p < 0.01 at each follow-up). The mean duration of surgery and uterus removal, as well as the estimated blood loss, were not significantly different between the two groups. CONCLUSIONS: The present study suggests that bupivacaine injection to trocar sites is an effective and safe method for reducing pain following laparoscopic hysterectomy.

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MeSH descriptors

Anesthetics, Local Laparoscopy Bupivacaine Double-Blind Method Female Humans Hysterectomy Hysterectomy Pain Measurement Postoperative Pain Postoperative Pain Postoperative Pain Postoperative Pain Prospective Studies Surgical Instruments

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chemicals 4
bupivacaine bupivacaine bupivacaine bupivacaine

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