Morbility Follow Up and Endocrine Disruption of Exposed Subjects

Paolo Mocarelli, Milano Bicocca
In: Epidemiology · 2006 · vol. 17(Suppl) , pp. S82–S83 · doi:10.1097/00001648-200611001-00194 · W1977642213
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This study monitored TCDD-exposed individuals, finding chloracne as the only significant clinical alteration, longer TCDD half-life in women, increased breast cancer risk, and a female-biased sex ratio at birth linked to paternal exposure.

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This study monitored thousands of individuals exposed to TCDD fallout in Seveso from 1976 to 2005, analyzing serum samples and clinical outcomes over decades. Key findings included chloracne as the primary clinical alteration linked to contamination levels, a longer half-life for TCDD in women compared to men, and a significantly increased hazard ratio for breast cancer associated with high serum TCDD levels. The researchers noted a doubled but nonsignificant risk for endometriosis in women with serum TCDD levels of 100 ppt or higher, alongside other reproductive and developmental effects such as menstrual cycle lengthening and skewed sex ratios at birth. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

WS1-03 Abstract: We monitored (from 1976–2005) thousands of people affected by the fallout of TCDD over Seveso on July 10, 1976. Serum samples have been kept frozen and it has been possible after 1988 to measure the TCDD blood lipid content. The results indicate that: Chloracne was the only clinical alteration, which partly correlated to TCDD contamination levels with differing individual susceptibility; and Miscarriages, perinatal mortality, low birth weight, and congenital malformations did not significantly increase. Part of the exposed subjects were followed up from 1992 to 2005. The results showed that: No pathologic laboratory results were related to TCDD levels; The half-life of TCDD was longer in women (approximately 9 years) than in men (approximately 7.5 years) and much shorter in children; A doubled, nonsignificant risk for endometriosis in women was associated with serum TCDD levels of 100 ppt or higher; Among premenarcheal women, serum TCDD level was associated with a lengthening of the menstrual cycle by 0.93 days; The hazard ratio for breast cancer associated with serum TCDD levels was significantly increased to 2.1; A skewing of the sex ratio at birth with an excess of females (P < 0.001) from parents exposed to TCDD was observed and it was permanently related only to exposure of the father; and Developmental dental aberrations were registered as well associated with childhood exposure.
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WS1-03 Abstract: We monitored (from 1976–2005) thousands of people affected by the fallout of TCDD over Seveso on July 10, 1976. Serum samples have been kept frozen and it has been possible after 1988 to measure the TCDD blood lipid content. The results indicate that: Chloracne was the only clinical alteration, which partly correlated to TCDD contamination levels with differing individual susceptibility; and Miscarriages, perinatal mortality, low birth weight, and congenital malformations did not significantly increase. Part of the exposed subjects were followed up from 1992 to 2005. The results showed that: No pathologic laboratory results were related to TCDD levels; The half-life of TCDD was longer in women (approximately 9 years) than in men (approximately 7.5 years) and much shorter in children; A doubled, nonsignificant risk for endometriosis in women was associated with serum TCDD levels of 100 ppt or higher; Among premenarcheal women, serum TCDD level was associated with a lengthening of the menstrual cycle by 0.93 days; The hazard ratio for breast cancer associated with serum TCDD levels was significantly increased to 2.1; A skewing of the sex ratio at birth with an excess of females (P < 0.001) from parents exposed to TCDD was observed and it was permanently related only to exposure of the father; and Developmental dental aberrations were registered as well associated with childhood exposure.

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endometriosis

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