CA-125 in peritoneal fluid from patients with nonmalignant gynecologic disorders

Ismail MA, M A Ismail, MOUSA ISMAIL, Jacob Rotmensch, J Rotmensch, Rotmensch J, L J Mercer, Mercer LJ, Barry S. Block, B S Block, Block BS, Salti GI, George I. Salti, G I Salti, John A. Holt, J A Holt, Holt JA
The Journal of reproductive medicine · 1994 · vol. 39(7) , pp. 510–2 · PMID:7966039 · W2416887126
Non-randomised trial OA: closed CC0 ⤵ 4 in-corpus citations
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Peritoneal fluid CA-125 levels were elevated in patients with benign gynecologic disorders compared to controls, but serum levels did not correlate and were not useful for diagnosis.

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Abstract

To assess the diagnostic value of measuring CA-125 levels in peritoneal fluid from women with nonmalignant gynecologic disorders, we determined CA-125 levels in peritoneal fluid and in serum collected simultaneously from 46 women undergoing gynecologic surgery. Patients with benign ovarian disease, non-ovarian gynecologic pathology and severe endometriosis had, on average, higher CA-125 levels in peritoneal fluid than did patients with a normal pelvis and those with mild endometriosis. There was no obvious correlation between peritoneal fluid and serum levels of CA-125. Our data show that (1) measurement of serum CA-125 levels is not useful for distinguishing between different benign gynecologic disorders, and (2) levels of CA-125 in peritoneal fluid in benign gynecologic disorders are comparable to the reported lower range of levels observed in women with intraperitoneal malignancies.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid CA-125 Antigen Genital Diseases, Female Aftercare Aftercare Ascitic Fluid Ascitic Fluid CA-125 Antigen CA-125 Antigen Confounding Factors, Epidemiologic Confounding Factors, Epidemiologic Diagnosis, Differential Diagnosis, Differential Female Female Genital Diseases, Female Genital Diseases, Female Genital Diseases, Female Genital Diseases, Female Humans

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europepmc
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License: CC0 · commercial use OK