Endometrial antibodies versus CA-125 for the detection of endometriosis

R A Wild, Wild RA, Hirisave V, V Hirisave, A Bianco, Bianco A, Podczaski ES, E S Podczaski, L M Demers, Demers LM
Fertility and sterility · 1991 · vol. 55(1) , pp. 90–4 · doi:10.1016/s0015-0282(16)54065-5 · PMID:1986975
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Evaluating 202 patient sera, this study found that endometrial antibody testing achieved higher sensitivity (83.1%) than CA-125 (27.3%) for detecting endometriosis, suggesting its potential utility as a diagnostic adjunct.

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Abstract

Detection of endometrial antibodies using an indirect immunofluorescence method along with a well-established human endometrial carcinoma cell line was evaluated and compared with CA-125 for detecting endometriosis. Two hundred two patient sera from the infertility, gynecological, and gynecological oncology services were evaluated. The sensitivity for antibody testing was 83.1% with a specificity of 78.8%, in contrast to a sensitivity of 27.3% and a specificity of 82.6% for CA-125. These preliminary findings offer promise that antibody detection methods may be a useful adjunct in the diagnosis of endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate Autoantibodies Biomarkers, Tumor Endometriosis Endometrium Uterine Neoplasms Adult Adult Antigens, Tumor-Associated, Carbohydrate Antigens, Tumor-Associated, Carbohydrate Autoantibodies Autoantibodies Biomarkers, Tumor Biomarkers, Tumor Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium

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europepmc
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pubmed
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