Relationship between the release of prolactin and endothelin-1 in human decidualized endometrial cells

T. Kubota, Tetsuo Kubota, M Taguchi, Makoto Taguchi, Katsuya Kobayashi, K Kobayashi, M Masuda, Takeshi Asô, T. Aso
European journal of endocrinology · 1997 · vol. 137(2) , pp. 200–204 · doi:10.1530/eje.0.1370200 · PMID:9272110 · W2098963739
Lab / animal OA: closed CC0 ⤵ 2 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-14 ⓘ

Decidualized endometrial cells showed decreased endothelin-1 and increased prolactin release, with TGF-beta 1 attenuating prolactin and increasing endothelin-1 in early pregnancy decidual cells.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The study was undertaken to investigate the interaction between the release of endothelin-1 (ET-1) and prolactin (PRL) from human decidualized endometrial cells, and the effects of transforming growth factor (TGF)-beta 1 on the release of ET-1 and PRL from human decidual cells in the early stage of pregnancy. Stromal cells derived from human endometrial tissues were cultured on a type-1 collagen membrane in serum-free medium with or without 100 nmol/l oestradiol and 1 mumol/l medroxyprogesterone acetate (MPA) for 12 days. In addition, decidual cells of early pregnancy were cultured with or without TGF-beta 1 for 48 h. PRL and ET-1 levels in the media were measured by a specific enzyme immunoassay and RIA respectively. In decidualized endometrial cells induced by ovarian steroid hormones in vitro, PRL release increased and ET-1 release decreased in a time-dependent manner. Ovarian steroid hormones significantly attenuated ET-1 release. In the decidual cells of early pregnancy, TGF-beta 1 significantly attenuated the PRL release, whereas this growth factor dose-dependently increased ET-1 release. There was a significant negative correlation between the release of PRL and that of ET-1. These results demonstrate that the regulation of PRL release is quite different from that of ET-1 release in the human decidualized endometrial cells, and suggest that TGF-beta 1 has significant effects on PRL and ET-1 release in the human decidua of early pregnancy.

My notes (saved in your browser only)

MeSH descriptors

Decidua Endometrium Endothelin-1 Prolactin Adult Cells, Cultured Decidua Decidua Dose-Response Relationship, Drug Endometrium Endometrium Endothelin-1 Female Humans Pregnancy Prolactin Time Factors Transforming Growth Factor beta Transforming Growth Factor beta

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (2)

Cited by (2)

References (29)

Cited by (2)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T22:00:22.376048+00:00
unpaywall
last seen: 2026-10-29T06:31:18.914191+00:00
License: CC0 · commercial use OK