Peritoneal and Peripheral B‐1‐Cell Populations in Patients with Endometriosis

Fumihisa Chishima, F Chishima, Satoshi Hayakawa, S Hayakawa, Y Hirata, N Nagai, Nobuhisa Nagai, Takashi Kanaeda, T Kanaeda, K Tsubata, Katsuo Tsubata, K Satoh, Kazuo Satoh
Journal of Obstetrics and Gynaecology Research · 2000 · vol. 26(2) , pp. 141–149 · doi:10.1111/j.1447-0756.2000.tb01298.x · W1986478664
article OA: closed CC0 ⤵ 19 in-corpus citations
View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Endometriosis patients showed increased peritoneal B-1 cells compared to controls, with peripheral B-1 cell levels correlating to antinuclear antibody production.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Abstract Objective: The purpose of this study was to investigate the frequency of B‐1 cells in the peritoneal cavity and peripheral blood of patients with endometriosis. Materials and Methods: We examined 31 patients with endometriosis and 14 normal nonpregnant women. Peripheral blood cells and peritoneal exudate cells (PECs) were stained with FITC or PE‐labeled anti‐CD5/CD19 monoclonal antibodies. Immunofluorescence analysis was performed using a flow cytometer. The significance of differences between the patient and control groups was determined by the non‐parametric Mann‐Whitney test. Results: There was no significant difference in the percentages of B‐1 cells in the peripheral blood of women with and without endometriosis (median, 22.7%; range, 4.7–92.3% vs median, 20.05%; range, 11.1–12.6%, respectively). Endometriosis patients with antinuclear antibodies (ANAs) demonstrated significantly elevated B‐1 cells compared to both endometriosis patients without ANAs and normal controls (p < 0.005 and p < 0.05, respectively). Endometriosis patients demonstrated significantly higher B‐1 cell populations (B‐1 cells/total B‐cell ratio) in PECs than did non‐endometriosis patients (p < 0.05). Conclusions: The peripheral B‐1‐cell population in patients with endometriosis is related to ANA production. B‐1 cells might play important roles in the development of endometriosis through autoantibody production.

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Blood Cells B-Lymphocyte Subsets Endometriosis Endometriosis Peritoneum Adult Antibodies, Monoclonal Blood Cells B-Lymphocyte Subsets Case-Control Studies CD5 Antigens Endometriosis Female Flow Cytometry Fluorescent Antibody Technique Humans Peritoneum Statistics, Nonparametric

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (43)

Cited by (19)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:13:36.046895+00:00
License: CC0 · commercial use OK