Immunosuppressive Extracellular Vesicles as a Linking Factor in the Development of Tumor and Endometriotic Lesions in the Gynecologic Tract

Karolina Soroczynska, Karolina Soroczyńska, Łukasz Zaręba, Magdalena Długołęcka, Malgorzata Czystowska
Cells · 2022 · vol. 11(9) , pp. 1483 · doi:10.3390/cells11091483 · PMID:35563789 · W4280584060
review OA: gold CC0 ⤵ 18 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Extracellular vesicles mediate immunosuppressive and pro-inflammatory mechanisms, creating favorable microenvironments for the development of gynecologic tumors and endometriosis.

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Abstract

Both gynecological tumors and endometriosis require for their development a favorable environment, termed in the case of tumors a "pre-metastatic niche" and in case of endometriosis a "pro-endometriotic niche". This is characterized by chronic inflammation and immunosuppression that support the further progression of initial lesions. This microenvironment is established and shaped in the course of a vivid cross-talk between the tumor or endometrial cells with other stromal, endothelial and immune cells. There is emerging evidence that extracellular vesicles (EVs) play a key role in this cellular communication, mediating both in tumors and endometriosis similar immunosuppressive and pro-inflammatory mechanisms. In this review, we discuss the latest findings about EVs as immunosuppressive factors, highlighting the parallels between gynecological tumors and endometriosis. Furthermore, we outline their role as potential diagnostic or prognostic biomarkers as well as their future in therapeutic applications.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Extracellular Vesicles Extracellular Vesicles Extracellular Vesicles Extracellular Vesicles Extracellular Vesicles Genital Neoplasms, Female Genital Neoplasms, Female Genital Neoplasms, Female Genital Neoplasms, Female Genital Neoplasms, Female Cell Communication Cell Communication Cell Communication Cell Communication Endometrium

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (18)

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