BMP15 mRNA profile in granulosa cells from endometriosis patients undergoing in vitro fertilization

Budi Wiweko, Pritta Ameilia Iffanolida, Z Rectifa, Naylah Muna, Kresna Mutia, Ririn Rahmala Febri, Sari Rahmawati, Oki Riayati, Andon Hestiantoro
In: Journal of Physics: Conference Series · 2018 · vol. 1073 , pp. 032052 · doi:10.1088/1742-6596/1073/3/032052 · W2891817877
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This study found that patients with endometriosis undergoing IVF had higher BMP15 mRNA levels in their granulosa cells compared to controls, although the difference was not statistically significant.

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This study investigated the mRNA levels of Bone Morphogenetic Protein 15 in granulosa cells obtained from patients with endometriosis undergoing in vitro fertilization. Researchers compared samples from twelve endometriosis patients against seven healthy controls using absolute quantitative real-time PCR to assess oocyte quality markers. The results indicated that while BMP15 expression was higher in the endometriosis group, the difference did not reach statistical significance, prompting a recommendation for further research to confirm these findings. This paper is centrally about endometriosis — specifically examining molecular markers in granulosa cells to understand their impact on oocyte quality and infertility associated with the condition.

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Abstract

Endometriosis is a female reproductive disorder that can cause infertility by lowering oocyte quality due to a low quality of oocytes. Granulosa cell assessment is a minimally invasive procedure for determining oocyte quality. Bone morphogenetic protein 15 (BMP15) also acts as a growth factor for oocyte derivatives that regulate proliferation and granulosa cell differentiation. In endometriosis, higher BMP15 expression is assumed to induce oocyte growth. This study aimed to determine the mRNA levels of BMP15 in granulosa cells from endometriosis patients undergoing in vitro fertilization. We analyzed samples from 12 patients with endometriosis and seven normal women using real-time PCR at Yasmin Clinic, Kencana, Cipto Mangunkusumo Hospital. Granulosa cells collected during oocyte retrieval were preserved using RNAlater® QIAGEN and were evaluated by absolute quantitative real-time PCR with pre-manufactured oligonucleotides as the standard. Results showed that although BMP15 did not significantly differ between the endometriosis patients and the controls (p > 0.05), the endometriosis patients had higher BMP15 mRNA levels than the controls. Therefore, further study is warranted to gain more comprehend data.
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Abstract Endometriosis is a female reproductive disorder that can cause infertility by lowering oocyte quality due to a low quality of oocytes. Granulosa cell assessment is a minimally invasive procedure for determining oocyte quality. Bone morphogenetic protein 15 (BMP15) also acts as a growth factor for oocyte derivatives that regulate proliferation and granulosa cell differentiation. In endometriosis, higher BMP15 expression is assumed to induce oocyte growth. This study aimed to determine the mRNA levels of BMP15 in granulosa cells from endometriosis patients undergoing in vitro fertilization. We analyzed samples from 12 patients with endometriosis and seven normal women using real-time PCR at Yasmin Clinic, Kencana, Cipto Mangunkusumo Hospital. Granulosa cells collected during oocyte retrieval were preserved using RNAlater® QIAGEN and were evaluated by absolute quantitative real-time PCR with pre-manufactured oligonucleotides as the standard. Results showed that although BMP15 did not significantly differ between the endometriosis patients and the controls (p > 0.05), the endometriosis patients had higher BMP15 mRNA levels than the controls. Therefore, further study is warranted to gain more comprehend data. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.

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