A scalable framework for benchmark embedding models in semantic health-care tasks

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This study benchmarks 39 embedding models across medical semantic tasks using real-world and synthetic data, finding that larger models excel in long-context retrieval while smaller models perform comparably in short tasks.

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This study introduces a scalable framework to benchmark text embedding models for semantic healthcare tasks, addressing the current lack of standardized evaluation methods. The authors evaluated 39 models across seven medical semantic similarity tasks using diverse datasets from Mount Sinai, MIMIC IV, PubMed, and synthetic sources, assessing performance via Spearman rank correlation and retrieval metrics. Results indicated that larger models generally outperformed smaller ones in long-context tasks, while some smaller models remained competitive in short tasks, demonstrating the framework's utility for selecting appropriate tools for applications like retrieval-augmented generation. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

OBJECTIVES: Text embeddings are promising for semantic tasks, such as retrieval augmented generation (RAG). However, their application in health care is underexplored due to a lack of benchmarking methods. We introduce a scalable benchmarking method to test embeddings for health-care semantic tasks. MATERIALS AND METHODS: We evaluated 39 embedding models across 7 medical semantic similarity tasks using diverse datasets. These datasets comprised real-world patient data (from the Mount Sinai Health System and MIMIC IV), biomedical texts from PubMed, and synthetic data generated with Llama-3-70b. We first assessed semantic textual similarity (STS) by correlating the model-generated similarity scores with noise levels using Spearman rank correlation. We then reframed the same tasks as retrieval problems, evaluated by mean reciprocal rank and recall at k. RESULTS: In total, evaluating 2000 text pairs per 7 tasks for STS and retrieval yielded 3.28 million model assessments. Larger models (>7b parameters), such as those based on Mistral-7b and Gemma-2-9b, consistently performed well, especially in long-context tasks. The NV-Embed-v1 model (7b parameters), although top in short tasks, underperformed in long tasks. For short tasks, smaller models such as b1ade-embed (335M parameters) performed on-par to the larger models. For long retrieval tasks, the larger models significantly outperformed the smaller ones. DISCUSSION: The proposed benchmarking framework demonstrates scalability and flexibility, offering a structured approach to guide the selection of embedding models for a wide range of health-care tasks. CONCLUSION: By matching the appropriate model with the task, the framework enables more effective deployment of embedding models, enhancing critical applications such as semantic search and retrieval-augmented generation (RAG).
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Abstract

Objectives: Text embeddings are promising for semantic tasks, such as retrieval augmented generation (RAG). However, their application in health care is underexplored due to a lack of benchmarking methods. We introduce a scalable benchmarking method to test embeddings for health-care semantic tasks.

Materials and methods

We evaluated 39 embedding models across 7 medical semantic similarity tasks using diverse datasets. These datasets comprised real-world patient data (from the Mount Sinai Health System and MIMIC IV), biomedical texts from PubMed, and synthetic data generated with Llama-3-70b. We first assessed semantic textual similarity (STS) by correlating the model-generated similarity scores with noise levels using Spearman rank correlation. We then reframed the same tasks as retrieval problems, evaluated by mean reciprocal rank and recall at k.

Results

In total, evaluating 2000 text pairs per 7 tasks for STS and retrieval yielded 3.28 million model assessments. Larger models (>7b parameters), such as those based on Mistral-7b and Gemma-2-9b, consistently performed well, especially in long-context tasks. The NV-Embed-v1 model (7b parameters), although top in short tasks, underperformed in long tasks. For short tasks, smaller models such as b1ade-embed (335M parameters) performed on-par to the larger models. For long retrieval tasks, the larger models significantly outperformed the smaller ones.

Discussion

The proposed benchmarking framework demonstrates scalability and flexibility, offering a structured approach to guide the selection of embedding models for a wide range of health-care tasks.

Conclusion

By matching the appropriate model with the task, the framework enables more effective deployment of embedding models, enhancing critical applications such as semantic search and retrieval-augmented generation (RAG).

Keywords

artificial intelligence; large language models; medical NLP tools. © The Author(s) 2025. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Conflict of interest statement The authors have no competing interests to declare. Figures

References

- - Lewis P, Perez E, Piktus A, et al. Retrieval-augmented generation for knowledge-intensive NLP tasks. Adv Neural Inf Process Syst. 2020;33:9459-9474. - - Muennighoff N, Tazi N, Magne L, Reimers N. MTEB: massive text embedding benchmark. arXiv, arXiv:221007316, 2022, preprint: not peer reviewed. - - medrxiv-clustering-p2p. 2022. Accessed September 10, 2025. https://huggingface.co/datasets/mteb/medrxiv-clustering-p2p Publication types MeSH terms Grants and funding LinkOut - more resources Full Text Sources

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Benchmarking Information Storage and Retrieval Information Storage and Retrieval Natural Language Processing Semantics Humans

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License: CC-BY-ND-4.0