Cissus quadrangularis prevented the ovariectomy induced oxidative stress in the femur of adult albino rats

Sridhar Muthusami, Vasudevan Gopalakrishnan, Jone A. Stanley, Senthilkumar Krishnamoorthy, Ramachandran Ilangovan, Velliyur Kanniappan Gopalakrishnan, Velliyur K Gopalakrishnan, Narasimhan Srinivasan
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2016 · vol. 81 , pp. 416–423 · doi:10.1016/j.biopha.2016.04.021 · PMID:27261621 · W2344414111
Lab / animal OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-10-05 ⓘ

Cissus quadrangularis administration prevented ovariectomy-induced oxidative stress and maintained antioxidant enzyme activities in the femurs of adult female rats.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

UNLABELLED: The increasing evidence suggesting the role of free radicals in bone resorption and bone loss prompted us to explore whether the consumption of antioxidant rich medicinal plant C. quadrangularis modifies antioxidant status in ovariectomized rats. METHODS: Twenty four female adult rats, 90days old showing regular estrous cycles were used for the present study. The animals were divided into two groups. The Group-1 rats (n=6) were sham operated and Group-II rats were bilaterally ovariectomized (n=18) and treated with C. quadrangularis for sixty days (100mg/kg body weight and 250mg/kg body weight). After sixty days, the rats were killed, femora were dissected out, minced and homogenized in Tris-HCl buffer (pH 7.4) and the supernatant was collected and used for biochemical assays. RESULTS: Ovariectomy registered a decrease (p<0.05) in the activities of SOD, GPx, GST, ALP, collagen content and increased (p<0.05) the activities of TRAP and lipid peroxidation. Simultaneous administration of C. quadrangularis maintained the enzyme activities in ovariectomized rats. CONCLUSION: C. quadrangularis, a natural herb may be used to treat the estrogen deficiency/menopause onset and ovariectomy induced oxidative stress.

My notes (saved in your browser only)

MeSH descriptors

Cissus Femur Femur Ovariectomy Oxidative Stress Plant Extracts Aging Alkaline Phosphatase Alkaline Phosphatase Animals Cissus Collagen Collagen Female Femur Femur Glutathione Peroxidase Glutathione Peroxidase Glutathione Transferase Glutathione Transferase

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (70)

SciLite annotations

organisms 13
winged treebine rattus sp. mosquito plant typhlosaurus cregoi rattus sp. rattus sp. multicellular animals rattus sp. rattus sp. typhlosaurus cregoi rattus sp. typhlosaurus cregoi rattus sp.
chemicals 1
lipid

Source provenance

openalex
last seen: 2026-05-11T05:56:47.744056+00:00
pubmed
last seen: 2026-10-08T21:17:59.733123+00:00
scilite
last seen: 2026-05-18T04:26:01.642840+00:00
unpaywall
last seen: 2026-10-25T06:24:14.523685+00:00
License: CC0 · commercial use OK