Effects of danazol on gonadotropin levels in castrated rhesus monkeys.
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Danazol administration to castrated female rhesus monkeys significantly decreased LH and FSH levels, demonstrating potent antigonadotropic activity likely acting at the hypothalamic level.
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Abstract
Danazol is widely used in the management of endometriosis and mammary dysplasia. However, its mechanism of action is still obscure because of the few studies done and the controversial results obtained. Antigonadotropic activity has been postulated by some investigators, whereas others have observed no effect on the gonads. In the present study, three castrated female rhesus monkeys received 400 mg of danazol daily, by gavage for 19 days, while 2 controls received 400 mg of lactose daily. Blood samples were drawn every other day from 2 weeks prior to 3 weeks after the administration of the drug. Plasma luteinizing hormone (LH) and follicle stimulating hormone (FSH) decreased rapidly and then were maintained until danazol was discontinued. Prompt return to pretreatment levels occurred 1-2 days after the discontinuation of therapy. Prolactin levels were normal during therapy. Luteinizing hormone releasing factor (LH-RF), 100 microgram, administered intravenously during danazol therapy, caused a normal, prompt release of gonadotropins, demonstrating an intact pituitary response. The authors conclude that 1) danazol is a potent antigonadotropic agent, 2) its effect is abolished promptly after discontinuation, and 3) its probable biological action is at the hypothalamic level.
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Cited by (18)
- Prolonged inhibition of normal ovarian cycles in the rat and cynomolgus monkeys following a single s.c. injection of danazol 1997
- Leukocyte Subpopulation Changes in Rats With Autotransplanted Endometrium and the Effect of Danazol 1995
- Thermoregulatory and endocrine effects of a low dose of danazol in postmenopausal women: Interaction with the effect of naloxone 1991
- Inhibition of gonadotropin-releasing hormone receptors in rat anterior pituitary monolayer cell cultures by danazol 1986
- Danazol inhibits steroidogenesis by the human ovary in vivo 1986
- Hot flashes in postmenopausal women ameliorated by danazol 1985
- Gynecologic Problems of Adolescence 1985
- The effect of danazol on gonadotropin secretion during the follicular phase of the menstrual cycle 1983
- Influence of danazol on cytoplasmic and nuclear estrogen binding capacity in the uterus 1983
- Effects of danazol on pulsatile gonadotropin patterns and on serum estradiol levels in normally cycling women 1983
- Danazol suppression of luteinizing hormone secretion: a role for danazol-androgen receptor interaction within the brain-pituitary complex 1981
- Actions of danazol in vivo on cytochrome P-450 and steroidogenic enzymes in rat testis and liver microsomal preparations 1981
- In Vitro Effect of Danazol on Luteinizing Hormone-Releasing Hormone-Stimulated Luteinizing Hormone Release in Rat Anterior Pituitary Cell Cultures in Vitro * 1981
- Danazol for benign breast disease 1980
- Mechanism of induction of luteal phase defects by danazol 1980
- Pharmacology and Pharmacokinetics of Danazol 1980
- Danazol binding and translocation of steroid receptors 1980
- Danazol Suppresses Luteal Function in Vitro and in Vivo 1980
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