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This randomized controlled trial evaluated the efficacy of combining laparoscopic surgery with gestrinone drug therapy in eighty patients diagnosed with endometriosis. The study found that the combination group experienced significantly lower intraoperative bleeding, shorter hospitalization stays, higher treatment effectiveness rates, and improved biomarker levels compared to the surgery-only control group. Additionally, the combined approach resulted in a zero percent recurrence rate versus twelve point five percent for surgery alone, alongside a significantly higher post-treatment pregnancy rate of twenty-seven point five percent compared to seven point five percent. This paper is centrally about endometriosis — specifically examining how adjunctive medical therapy enhances surgical outcomes and fertility restoration in affected patients.
Abstract
Objective
To analyze the therapeutic effect of laparoscopic surgery combining drug therapy for endometriosis patients and to observe its effect on the patients’ reproductive function.
Methods
80 patients with endometriosis treated at our department were randomly divided into a control group (n=40), laparoscopicly treated, and a study group (n=40), laparoscopicly treated and were given gestrinone. After treatment, the treatment effect and fertility were evaluated.
Results
The intraoperative bleeding volume was significantly lower and the hospitalization time shorter in the observation group than in the control group (P 0.05) . The total effective rate was 92.50% in the observation group and was 75.0% in the control group (P 0.05) . After the treatment, FSH, E2, and CA125 were significantly improved both groups (P 0.05) . The reproductive function recovery time was significantly shorter in the observation group than in the control group. The pregnancy rate was 27.5% in the observation group and was 7.5% in the control group (P<0.05) .
Conclusions
Laparoscopic surgery combining drug therapy has a significant effect on patients with endometriosis and can promote the recovery of fertility function and reduce the recurrence of endometriosis.
Key words:
Endometriosis; Laparoscope; gestrinone; Effect; Fertility function
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腹腔镜联合药物治疗子宫内膜异位症的疗效及对患者生育功能的影响分析
Laparoscopy combining drug therapy for endometriosis and its effect on patients' reproductive function
摘要目的 分析子宫内膜异位症患者采用腹腔镜手术与药物疗法联合治疗的疗效,并观察其对患者生育功能造成的影响.方法 收集本科室接收的患子宫内膜异位症患者80例,随机分成两组:参照组40例,单行腹腔镜手术治疗;研究组40例,在参照组的基础上加用孕三烯酮辅助治疗;评估治疗后患者的疗效及观察患者治疗后的生育状况.结果 观察组患者在术中出血量和住院时间均明显少于对照组(均P＜ 0.05),而在其他三项指标的比较中差异无统计学意义(均P＞ 0.05);研究组患者治疗总有效率为92.5％,明显高于参照组的75.0％ (P＜0.05);在卵泡刺激素(FSH)、雌二醇(E2)和糖类抗原125(CA125)三项指标的比较中,两组患者治疗前差异均无统计学意义(均P＞0.05),而治疗后均得到明显改善(均P＜ 0.05),且研究组改善程度明显高于参照组(P＜0.05);研究组病灶无复发,明显低于参照组的12.5％(P＜0.05);两组患者并发症发生情况比较,差异无统计学意义(P＞0.05);研究组患者在术后生育功能恢复时间明显短于参照组,研究组患者妊娠率为27.5％,参照组为7.5％,两组比较差异均有统计学意义(均P＜ 0.05).结论 子宫内膜异位症患者采用腹腔镜手术与药物疗法联合治疗疗效显著,且可促进患者生育功能的恢复,减少复发.
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abstractsObjective To analyze the therapeutic effect of laparoscopic surgery combining drug therapy for endometriosis patients and to observe its effect on the patients' reproductive function.Methods 80 patients with endometriosis treated at our department were randomly divided into a control group (n=40),laparoscopicly treated,and a study group (n=40),laparoscopicly treated and were given gestrinone.After treatment,the treatment effect and fertility were evaluated.Results The intraoperative bleeding volume was significantly lower and the hospitalization time shorter in the observation group than in the control group (P ＜ 0.05);there were no statistical differences in the other three indicators between these two groups (P ＞ 0.05).The total effective rate was 92.50％ in the observation group and was 75.0％ in the control group (P ＜ 0.05).There were no statistical differences in follicle stimulating hormone (FSH),estradiol (E2),and carbohydrate antigen 125 (CA125)between these two groups before the treatment (P ＞ 0.05).After the treatment,FSH,E2,and CA125 were significantly improved both groups (P ＜ 0.05) and were remarkably higher in the observation group group than in the control group (P ＜ 0.05).The recurrence rate was 0.0％ in the observation group and was 12.5％ in the control group (P ＜ 0.05).There was no statistical difference in the incidence of complications between these two groups (P ＞ 0.05).The reproductive function recovery time was significantly shorter in the observation group than in the control group.The pregnancy rate was 27.5％ in the observation group and was 7.5％ in the control group (P ＜ 0.05).Conclusions Laparoscopic surgery combining drug therapy has a significant effect on patients with endometriosis and can promote the recovery of fertility function and reduce the recurrence of endometriosis.
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