Medikamentöse und konservative Therapie

In: Endometriose · 2004 · pp. 171–230 · doi:10.1007/978-3-7091-0574-0_6 · W2132797363
book-chapter OA: closed CC0 ⤵ 1 in-corpus citation
Full text JSON View on OpenAlex View at publisher
AI-generated summary by claude@2026-06+body, 2026-06-07

Endometriosis treatment aims to eliminate lesions, prevent recurrence, and improve symptoms or fertility, typically involving surgery followed by medication and potentially a second surgery.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text

The paper discusses the treatment aims and a staged therapeutic concept for endometriosis, describing an initial surgical step for definitive histologic diagnosis (including laparoscopy with biopsy, adhesiolysis, and coagulation, with laparotomy when necessary), followed by medical add-on therapy and, when indicated, a “second look” operation. It summarizes that after primary surgery, medication such as GnRH agonists for 3–6 months may be used, and that a second-look procedure two months after medication can allow micro-surgical reconstruction and resection of residual disease, with organ-preserving strategies when fertility is desired. A key caveat is that the framework is largely experiential and conditional on extent of findings and clinical goals, rather than presenting a single new comparative efficacy study. This paper is centrally about endometriosis — it lays out the stepwise surgical and medical treatment strategy for preventing new lesions and achieving symptom improvement or fertility outcomes.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 22,380 characters · extracted from oa-doi-fallback · click to expand
Zusammenfassung Ziel der Behandlung einer Endometriose ist die Beseitigung bestehender bzw. die Verhinderung des Auftretens neuer Endometrioseherde. Zumindest sollte die Behandlung zu einer längerfristigen Besserung von Symptomen oder/und Erfüllung eines bestehenden Kinderwunsches führen. Die Therapie der Endometriose stützt sich erfahrungsgemäß auf ein Dreistufenkonzept (Tabelle 1): 1. Primäroperation mit Laparoskopie zur definitiven histologischen Diagnose der Endometriose durch Biopsie, Adhäsiolyse und Koagulation makroskopisch erkennbarer Endometrioseherde und suspekter Areale, ggf. ist auch die Durchführung einer Laparotomie zur Sanierung ausgedehnter Endometriosebefunde erforderlich. 2. Nach primär operativem Vorgehen, kann sich eine medikamentöse Nachbehandlung z.B. mit gonadotropin releasing hormon (GnRH)-Agonisten über 3–6 Monate anschließ en (Dmowski et al. 1990, Buttram 1993). 3. Zwei Monate nach Abschluss der Medikationsphase kann eine second look Operation mit der Möglichkeit der Anwendung mikrochirurgischer, rekonstruktiver Verfahren erfolgen. Bei primär ausgedehnten Befunden sollte nun die Sanierung und ggf. Resektion von Restbefunden erfolgen. Dies kann auch die Resektion betroffener Darm- oder Blasenabschnitte beinhalten. Bei Kinderwunsch ist ein primär organerhaltendes Vorgehen zu wählen. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others Literatur Adamson GD (1997) Treatment of endometriosis-associated infertility. Semin Reprod Endocrinol 15: 263–271 Adamson GD, Pasta DJ (1994) Surgical treatment of endometriosis-associated infertility: meta-analysis compared with survival analysis. Am J Obstet Gynecol 171: 1488–1504; discussion 1504-1485 Aloia JF, Vaswani A, Yeh JK, Ross PL, Flaster E, Dilmanian FA (1994) Calcium supplementation with and without hormone replacement therapy to prevent postmenopausal bone loss. Ann Intern Med 120: 97–103 Aoki TT, Grecu EO, Srinivas PR, Prescott P, Benbarka M, Arcangeli MM (2000) Prevalence of osteoporosis in women: variation with skeletal site of measurement of bone mineral density. Endocr Pract 6: 127–131 Ayers JW, Birenbaum DL, Menon KM (1987) Luteal phase dysfunction in endometriosis: elevated progesterone levels in peripheral and ovarian veins during the follicular phase. Fertil Steril 47: 925–929 Baran D, Sorensen A, Grimes J, Lew R, Karellas A, Johnson B, Roche J (1989) Dietary modification with dairy products for preventing vertebral bone loss in postmenopausal women: a three-year prospective study. J Clin Endocrinol Metab 70: 264–270 Bartosik D, Damjanov I, Viscarello RR, Riley JA (1987) Immunoproteins in the endometrium: clinical correlates of the presence of complement fractions C3 and C4. Am J Obstet Gynecol 156: 11–15 Brosens IA (1994) New principles in the management of endometriosis. Acta Obstet Gynecol Scand [Suppl] 159: 18–21 Brosens IA, Koninckx PR, Corveleyn PA (1978) A study of plasma progesterone, oestradiol-17beta, prolactin and LH levels, and of the luteal phase appearance of the ovaries in patients with endometriosis and infertility. Br J Obstet Gynaecol 85: 246–250 Busacca M, Bianchi S, Agnoli B, Candiani M, Calia C, De Marinis S, Vignali M (1999) Follow-up of laparoscopic treatment of stage III-IV endometriosis. J Am Assoc Gynecol Laparosc 6: 55–58 Cahill DJ, Hull MG (2000) Pituitary-ovarian dysfunction and endometriosis. Hum Reprod Update 6: 56–66 Candiani GB, Fedele L, Vercellini P, Bianchi S, Di Nola G (1991) Repetitive conservative surgery for recurrence of endometriosis. Obstet Gynecol 77: 421–424 Cann CE (1998) Bone densitometry as an adjunct to GnRH agonist therapy J Reprod Med 43: 321–330 Chapuy MC, Chapuy P, Meunier PJ (1987) Calcium and vitamin D supplements: effects on calcium metabolism in the elderly. Am J Clin Nutr 46: 324 Chavassieux P, Garnero P, Duboeuf F, Vergnaud P, Brunner-Ferber F, Delmas PD, Meunier PJ (2001) Effects of a new selective estrogen receptor modulator (MDL 103,323) on cancellous and cortical bone in ovariectomized ewes: a biochemical, histomorphometric, and densitometric study. J Bone Miner Res 16: 89–96 Cheesman KL, Cheesman SD, Chatterton RT Jr, Cohen MR (1983) Alterations in progesterone metabolism and luteal function in infertile women with endometriosis. Fertil Steril 40: 590–595 Chung HW, Lee JY, Moon HS, Hur SE, Park MH, Wen Y, Polan ML (2002) Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium. Fertil Steril 78: 787–795 Chwalisz K (2003) New selective progesterone receptor modulators (SPRMs) in the treatment of endometriosis. 19th ESHRE Annual Meeting xviii 87–88 Crosignani PG, Vercellini P, Biffignandi F, Costantini W, Cortesi I, Imparato E (1996) Laparoscopy versus laparotomy in conservative surgical treatment for severe endometriosis. Fertil Steril 66: 706–711 Dawood MY (1993) Impact of medical treatment of endometriosis on bone mass. Am J Obstet Gynecol 168: 674–684 D'Hooghe TM (2003) Immunomodulators and aromatase inhibitors: are they the next generation of treatment for endometriosis? Curr Opin Obstet Gynecol 15: 243–249 Dicker D, Goldman JA, Levy T, Feldberg D, Ashkenazi J (1992) The impact of long-term gonadotropin-releasing hormone analogue treatment on preclinical abortions in patients with severe endometriosis undergoing in vitro fertilization-embryo transfer. Fertil Steril 57: 597–600 Dmowski WP (1979) Endocrine properties and clinical application of danazol. Fertil Steril 31: 237–251 Donnez J, Squifflet J, Pirard C, Jadoul P, Wyns C, Smets M (2002) The efficacy of medical and surgical treatment of endometriosis-associated infertility and pelvic pain. Gynecol Obstet Invest 54[Suppl 1]: 2–10 el-Roeiy A, Dmowski WP, Gleicher N, Radwanska E, Harlow L, Binor Z, Tummon I, Rawlins RG (1988) Danazol but not gonadotropin-releasing hormone agonists suppresses autoantibodies in endometriosis. Fertil Steril 50: 864–871 Evans A, Vollenhoven B, Healy D (1999) Modern antioestrogens and the coming revolution in women's health care. Aust NZ J Obstet Gynaecol 39: 334–340 Fahraeus L, Sydsjo A, Wallentin L (1986) Lipoprotein changes during treatment of pelvic endometriosis with medroxyprogesterone acetate. Fertil Steril 45: 503–506 Falcone T, Goldberg JM, Miller KF (1996) Endometriosis: medical and surgical intervention. Curr Opin Obstet Gynecol 8: 178–183 Fedele L, Bianchi S, Zanconato G, Portuese A, Raffaelli R (2001) Use of a levonorgestrel-releasing intrauterine device in the treatment of rectovaginal endometriosis. Fertil Steril 75: 485–488 Fedele L, Marchini M, Bianchi S, Dorta M, Arcaini L, Fontana PE (1990) Structural and ultrastructural defects in preovulatory endometrium of normo-ovulating infertile women with minimal or mild endometriosis. Fertil Steril 53: 989–993 Felberbaum RE, Kupker W, Diedrich K (2002) Will GnRH antagonists assist in the treatment of benign gynaecological diseases? Reprod Biomed Online 5: 68–72 Felberbaum RE, Ludwig M, Diedrich K (2000) Clinical application of GnRH-antagonists. Mol Cell Endocrinol 166: 9–14 Franke HR, van de Weijer PH, Pennings TM, van der Mooren MJ (2000) Gonadotropin-releasing hormone agonist plus „add-back“ hormone replacement therapy for treatment of endometriosis: a prospective, randomized, placebo-controlled, double-blind trial. Fertil Steril 74: 534–539 Fujimoto J, Ichigo S, Hirose R, Sakaguchi H, Tamaya T (1997) Expression of estrogen receptor wild type and exon 5 splicing variant mRNAs in normal and endometriotic endometria during the menstrual cycle. Gynecol Endocrinol 11: 11–16 Garrido N, Navarro J, Garcia-Velasco J, Remoh J, Pellice A, Simon C (2002) The endometrium versus embryonic quality in endometriosis-related infertility. Hum Reprod Update 8: 95–103 Gilabert-Estelles J, Estelies A, Gilabert J, Castello R, Espana F, Falco C, Romeu A, Chirivella M, Zorio E, Aznar J (2003) Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis. Hum Reprod 18: 1516–1522 Goulding A, Gold E, Feng W (1992) Tamoxifen in the rat prevents estrogen-deficiency bone loss elicited with the LHRH agonist buserelin. Bone Miner 18: 143–152 Greenblatt RB, Dmowski WP, Mahesh VB, Scholer HF (1971) Clinical studies with an antigonadotropin — danazol. Fertil Steril 22: 102–112 Group TECW (2001) Ovarian and endometrial function during hormonal contraception. Hum Reprod 16: 1527–1535 Halme J, Becker S, Haskill S (1987) Altered maturation and function of peritoneal macrophages: possible role in pathogenesis of endometriosis. Am J Obstet Gynecol 156: 783–789 Heaney RP (1992) Calcium in the prevention and treatment of osteoporosis. J Intern Med 231: 169–180 Henkler G, Klotzbach M, Koch H, Muller W, Richter J (1982) Progress in the area of drug development, 15. Pharmazie 37: 753–765 Hii LL, Rogers PA (1998) Endometrial vascular and glandular expression of integrin alpha(v)beta3 in women with and without endometriosis. Hum Reprod 13: 1030–1035 Hornstein MD, Surrey ES, Weisberg GW, Casino LA (1998) Leuprolide acetate depot and hormonal add-back in endometriosis: a 12-month study. Lupron Add-Back Study Group. Obstet Gynecol 91: 16–24 Howell R, Edmonds DK, Dowsett M, Crook D, Lees B, Stevenson JC (1995) Gonadotropin-releasing hormone analogue (goserelin) plus hormone replacement therapy for the treatment of endometriosis: a randomized controlled trial. Fertil Steril 64: 474–481 Hughes EG, Fedorkow DM, Collins JA (1993) A quantitative overview of controlled trials in endometriosis-associated infertility. Fertil Steril 59: 963–970 Isaacson KB, Galman M, Coutifaris C, Lyttle CR (1990) Endometrial synthesis and secretion of complement component-3 by patients with and without endometriosis. Fertil Steril 53: 836–841 Jones KD, Sutton CJ (2002) Pregnancy rates following ablative laparoscopic surgery for endometriomas. Hum Reprod 17: 782–785 Kaunitz AM (1999) Oral contraceptive health benefits: perception versus reality. Contraception 59: 29S–33S Kauppila A, Rajaniemi H, Ronnberg L (1982) Low LH (hCG) receptor concentration in ovarian follicles in endometriosis. Acta Obstet Gynecol Scand 61: 81–83 Kauppila A, Vierikko P, Isotalo H, Ronnberg L, Vihko R (1984) Cytosol estrogen and progestin receptor concentrations and 17 beta-hydroxysteroid dehydrogenase activities in the endometrium and endometriotic tissue. Effects of hormonal treatment. Acta Obstet Gynecol Scand Suppl 123: 45–49 Kiesel L, Runnenbaum B (1993) Gonadotropin-releasing-Hormon und Analoga. Physiologie und Pharmakologie. Gynäkol Geburtsh Rundsch 32: 22 Kiesel L, Schweppe KW, Sillem M, Siebzehnrubl E (1996) Should add-back therapy for endometriosis be deferred for optimal results? Br J Obstet Gynaecol 103[Suppl 14]: 15–17 Krumlauf R (1994) Hox genes in vertebrate development. Cell 78: 191–201 Küpker W, Felberbaum RE, Krapp M, Schill T, Malik E, Diedrich K (2002) Use of GnRH antagonists in the treatment of endometriosis. Reprod Biomed Online 5: 12–16 Leather AT, Studd JW, Watson NR, Holland EF (1993) The prevention of bone loss in young women treated with GnRH analogues with „add-back“ estrogen therapy. Obstet Gynecol 81: 104–107 Lemay A, Maheux R, Faure N, Jean C, Fazekas AT (1984) Reversible hypogonadism induced by a luteinizing hormone-releasing hormone (LH-RH) agonist (Buserelin) as a new therapeutic approach for endometriosis. Fertil Steril 41: 863–871 Lessey BA, Castelbaum AJ, Sawin SW, Buck CA, Schinnar R, Bilker W, Strom BL (1994) Aberrant integrin expression in the endometrium of women with endometriosis. J Clin Endocrinol Metab 79: 643–649 Lipson A, Stoy DB, LaRosa JC, Muesing RA, Cleary PA, Miller VT, Gilbert PR, Stadel B (1986) Progestins and oral contraceptive-induced lipoprotein changes: a prospective study. Contraception 34: 121–134 Lu PY, Ory SJ (1995) Endometriosis: current management. Mayo Clin Proc 70: 453–463 Lu Y, Genant HK, Shepherd J, Zhao S, Mathur A, Fuerst TP, Cummings SR (2001) Classification of osteoporosis based on bone mineral densities. J Bone Miner Res 16: 901–910 Marcoux S, Maheux R, Berube S (1997) Laparoscopic surgery in infertile women with minimal or mild endometriosis. Canadian Collaborative Group on Endometriosis. N Engl J Med 337: 217–222 Marcus SF, Edwards RG (1994) High rates of pregnancy after long-term down-regulation of women with severe endometriosis. Am J Obstet Gynecol 171: 812–817 Matsuo H (2003) Bone loss induced by GnRHa treatment in women. Nippon Rinsho 61: 314–318 McBean JH, Brumsted JR (1993) In vitro CA-125 secretion by endometrium from women with advanced endometriosis. Fertil Steril 59: 89–92 McGinnis W, Krumlauf R (1992) Homeobox genes and axial patterning. Cell 68: 283–302 Milingos S, Kallipolitis G, Loutradis D, Liapi A, Drakakis P, Antsaklis A, Michalas S (1998) Factors affecting postoperative pregnancy rate after endoscopic management of large endometriomata. Int J Gynaecol Obstet 63: 129–137 Miller PD, Njeh CF, Jankowski LG, Lenchik L (2002) What are the standards by which bone mass measurement at peripheral skeletal sites should be used in the diagnosis of osteoporosis? J Clin Densitom 5: S39–45 Mills MS, Eddowes HA, Cahill DJ, Fahy UM, Abuzeid MI, McDermott A, Hull MG (1992) A prospective controlled study of in-vitro fertilization, gamete intra-fallopian transfer and intrauterine insemination combined with superovulation. Hum Reprod 7: 490–494 Moghissi KS (1996) Add-back therapy in the treatment of endometriosis: the North American experience. Br J Obstet Gynaecol 103[Suppl 14]: 14 Moghissi KS, Boyce CR (1976) Management of endometriosis with oral medroxyprogesterone acetate. Obstet Gynecol 47: 265–267 Muse K, Wilson EA, Jawad MJ (1982) Prolactin hyperstimulation in response to thyrotropin-releasing hormone in patients with endometriosis. Fertil Steril 38: 419–422 Nakamura K, Oosawa M, Kondou I, Inagaki S, Shibata H, Narita O, Suganuma N, Tomoda Y (1992) Menotropin stimulation after prolonged gonadotropin releasing hormone agonist pretreatment for in vitro fertilization in patients with endometriosis. J Assist Reprod Genet 9: 113–117 Noble LS, Simpson ER, Johns A, Bulun SE (1996) Aromatase expression in endometriosis. J Clin Endocrinol Metab 81: 174–179 Olive DL, Schwartz LB (1993) Endometriosis. N Engl J Med 328: 1759–1769 Osteen KG, Bruner-Tran KL, Ong D, Eisenberg E (2002) Paracrine mediators of endometrial matrix metalloproteinase expression: potential targets for progestin-based treatment of endometriosis. Ann NY Acad Sci 955: 139–146; discussion 157-138, 396-406 Ota H, Igarashi S, Hatazawa J, Tanaka T (1997) Distribution of heat shock proteins in eutopic and ectopic endometrium in endometriosis and adenomyosis. Fertil Steril 68: 23–28 Ota H, Tanaka T (1997) Integrin adhesion molecules in the endometrial glandular epithelium in patients with endometriosis or adenomyosis. J Obstet Gynaecol Res 23: 485–491 Padilla SL (1993) Ovarian abscess following puncture of an endometrioma during ultrasound-guided oocyte retrieval. Hum Reprod 8: 1282–1283 Pagidas K, Falcone T, Hemmings R, Miron P (1996) Comparison of reoperation for moderate (stage III) and severe (stage IV) endometriosis-related infertility with in vitro fertilization-embryo transfer. Fertil Steril 65: 791–795 Pal L, Shifren JL, Isaacson KB, Chang Y, Leykin L, Toth TL (1998) Impact of varying stages of endometriosis on the outcome of in vitro fertilization — embryo transfer. J Assist Reprod Genet 15: 27–31 Palomba S, Orio F Jr, Morelli M, Russo T, Pellicano M, Nappi C, Mastrantonio P, Lombardi G, Colao A, Zullo F (2002) Raloxifene administration in women treated with gonadotropin-releasing hormone agonist for uterine leiomyomas: effects on bone metabolism. J Clin Endocrinol Metab 87: 4476–4481 Paulson JD, Asmar P, Saffan DS (1991) Mild and moderate endometriosis. Comparison of treatment modalities for infertile couples. J Reprod Med 36: 151–155 Pellicer A, Albert C, Garrido N, Navarro J, Remohi J, Simon C (2000) The pathophysiology of endometriosis-associated infertility: follicular environment and embryo quality. J Reprod Fertil [Suppl] 55: 109–119 Pierce SJ, Gazvani MR, Farquharson RG (2000) Long-term use of gonadotropin-releasing hormone analogs and hormone replacement therapy in the management of endometriosis: a randomized trial with a 6-year follow-up. Fertil Steril 74: 964–968 Pittaway DE, Maxson W, Daniell J, Herbert C, Wentz AC(1983) Luteal phase defects in infertility patients with endometriosis. Fertil Steril 39: 712–713 Pouly JL, Drolet J, Canis M, Boughazine S, Mage G, Bruhat MA, Wattiez A (1996) Laparoscopic treatment of symptomatic endometriosis. Hum Reprod 11[Suppl 3]: 67–88 Prentice A, Deary AJ, Goldbeck-Wood S, Farquhar C, Smith SK (2000) Gonadotrophinreleasing hormone analogues for pain associated with endometriosis. Cochrane Database Syst Rev 2 Rana N, Thomas S, Rotman C, Dmowski WP (1996) Decrease in the size of ovarian endometriomas during ovarian suppression in stage IV endometriosis. Role of preoperative medical treatment. J Reprod Med 41: 384–392 Redegeld M, Weiß L, Denecke H, Glier B, Klinger R, Kröner-Herwig B, Nilges P (1955) Qualitätssicherung in der Therapie chronischer Schmerzen. Ergebnisse einer Arbeitsgruppe der Deutschen Gesellschaft zum Studium des Schmerzes (DGSS) zur psychologischen Diagnostik — II. Verfahren zur Erfassung des Schmerzerlebens. III. Verfahren zur Erfassung des Schmerzverhaltens. IV. Verfahren zur Erfassung der Schmerzintensität und Schmerztagebücher. Der Schmerz 9: 151–158 Reissmann T, Felberbaum R, Diedrich K, Engel J, Comaru-Schally AM, Schally AV (1995) Development and applications of luteinizing hormone-releasing hormone antagonists in the treatment of infertility: an overview. Hum Reprod 10: 1974–1981 Rickes D, Nickel I, Kropf S, Kleinstein J (2002) Increased pregnancy rates after ultralong postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis. Fertil Steril 78: 757–762 Schmidt CL (1985) Endometriosis: a reappraisal of pathogenesis and treatment. Fertil Steril 44: 157–173 Schweppe KW (1999) Aktive und inaktive Endometriose — eine prognose-und therapierelevante Differentioldiagnose. Zentralbl Gynäkol 121: 330–335 Sharpe-Timms KL, Cox KE (2002) Paracrine regulation of matrix metalloproteinase expression in endometriosis. Ann NY Acad Sci 955: 147–156; discussion 157-148, 396-406 Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N, Jaffe RB, Taylor RN (1996) Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab 81: 3112–3118 Sillem M, Prifti S, Monga B, Buvari P, Shamia U, Runnebaum B (1997) Soluble urokinase-type plasminogen activator receptor is over-expressed in uterine endometrium from women with endometriosis. Mol Hum Reprod 3: 1101–1105 Sulak PJ (1999) Oral contraceptives: therapeutic uses and quality-of-life benefits — case presentations. Contraception 59: 35S–38S Surrey ES (1999) Add-back therapy and gonadotropin-releasing hormone agonists in the treatment of patients with endometriosis: can a consensus be reached? Add-Back Consensus Working Group. Fertil Steril 71: 420–424 Surrey ES, Silverberg KM, Surrey MW, Schoolcraft WB (2002) Effect of prolonged gonadotropin-releasing hormone agonist therapy on the outcome of in vitro fertilization — embryo transfer in patients with endometriosis. Fertil Steril 78: 699–704 Taylor HS, Bagot C, Kardana A, Olive D, Arici A (1999) HOX gene expression is altered in the endometrium of women with endometriosis. Hum Reprod 14: 1328–1331 Taylor HS, Vanden Heuvel GB, Igarashi P (1997) A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes. Biol Reprod 57: 1338–1345 Tinkanen H, Kujansuu E (2000) In vitro fertilization in patients with ovarian endometriomas. Acta Obstet Gynecol Scand 79: 119–122 Tseng JF, Ryan IP, Milam TD, Murai JT, Schriock ED, Landers DV, Taylor RN (1996) Interleukin-6 secretion in vitro is up-regulated in ectopic and eutopic endometrial stromal cells from women with endometriosis. J Clin Endocrinol Metab 81: 1118–1122 Ueda M, Yamashita Y, Takehara M, Terai Y, Kumagai K, Ueki K, Kanda K, Hung YC, Ueki M (2002) Gene expression of adhesion molecules and matrix metalloproteinases in endometriosis. Gynecol Endocrinol 16: 391–402 Venturini PL, Fasce V, Gorlero F, Ginocchio G (1997) Chronic pelvic pain: oral contraceptives and non-steroidal anti-inflammatory compounds. Cephalalgia 17[Suppl 20]: 29–31 Vercammen EE, D'Hooghe TM (2000) Endometriosis and recurrent pregnancy loss. Semin Reprod Med 18: 363–368 Vercellini P, Ragni G, Trespidi L, Oldani S, Crosignani PG (1993) Does contraception modify the risk of endometriosis? Hum Reprod 8: 547–551 von Holst T (2000) Alternatives to hormone replacement therapy: raloxifene and tibolone. Z Arztl Fortbild Qualitatssich 94: 205–209 Waller KG, Shaw RW (1993) Gonadotropin-releasing hormone analogues for the treatment of endometriosis: long-term follow-up. Fertil Steril 59: 511–515 Wehren LE (2002) The role of the primary care physician in diagnosis and management of osteoporosis. Int J Fertil Womens Med 47: 116–122 Witz CA, Montoya IA, Dey TD, Schenken RS (1994) Characterization of lymphocyte subpopulations and T cell activation in endometriosis. Am J Reprod Immunol 32: 173–179 Woodson G (2000) Dual X-ray absorptiometry T-score concordance and discordance between the hip and spine measurement sites. J Clin Densitom 3: 319–324 Zeitoun KM, Bulun SE (1999) Aromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target. Fertil Steril 72: 961–969 Author information Authors and Affiliations Rights and permissions Copyright information © 2004 Springer-Verlag Wien About this chapter Cite this chapter Finas, D., Küpker, W., Diedrich, K., Felberbaum, R. (2004). Medikamentöse und konservative Therapie. In: Endometriose. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0574-0_6 Download citation DOI: https://doi.org/10.1007/978-3-7091-0574-0_6 Publisher Name: Springer, Vienna Print ISBN: 978-3-7091-7196-7 Online ISBN: 978-3-7091-0574-0 eBook Packages: Springer Book Archive

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK